ArticleForensic toxicology2016
Vitreous humor analysis for the detection of xenobiotics in forensic toxicology: a review.
Article in Forensic toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Thanatochemistry and the role of hypoxanthine in the post-mortem interval estimation: a systematic literature review.International journal of legal medicine · 2025Pooled it
- The biochemistry of the vitreous humour in estimating the post-mortem interval-a review of the literature, and use in forensic practice in Galicia (northwestern Spain).Forensic science, medicine, and pathology · 2023Pooled it
- Evaluation of bladder wash for postmortem toxicological analysis: Comparison with urine in 50 forensic cases.International journal of legal medicine · 2026Article
- Development and validation of a multi-matrix LC-MS/MS method for quantification of 20 drugs in human postmortem and porcine surrogate matrices.Analytical and bioanalytical chemistry · 2026Article
- Postmortem toxicological investigations in cases with an extended postmortem interval and advanced decomposition.International journal of legal medicine · 2026Review
- Cerebrospinal fluid as a post-mortem toxicological matrix: qualitative reliability and quantitative limitations in a cocaine-positive cases.Forensic science, medicine, and pathology · 2026Article
- Review
- Characterization of hydrolase activity in ocular tissues of humans and preclinical species.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- Electromembrane extraction (EME)-LC-MS/MS of khat: improving separation and determination of bioactive ingredients in traditional plant and vitreous humor.Forensic toxicology · 2025Article
- Analysis of the Correlation Between Cardiac Markers in Post-Mortem Vitreous Humor and the Perimortem Agony Interval.International journal of molecular sciences · 2025Article
- Delphinid postmortem vitreous humor biochemistry as proxy for antemortem blood analyte concentrations.Marine Mammal Science · 2025Article
- Vitreous humor in the forensic toxicology of quetiapine and its metabolites.Forensic toxicology · 2024Article
- Quantification of 108 illicit drugs and metabolites in bile matrix by LC-MS/MS for the toxicological testing of sudden death cases.Archives of toxicology · 2024Article
- Article
- Morphine pharmacokinetics and opioid transporter expression at the blood-retina barrier of male and female mice.Frontiers in pharmacology · 2023Article
- A sustainable approach for the stability study of psychotropic substances using vitreous humor and liver as alternative matrices.Analytical and bioanalytical chemistry · 2022Article
- Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices.Molecules (Basel, Switzerland) · 2022Review
- Methadone, Buprenorphine, Oxycodone, Fentanyl and Tramadol in Multiple Postmortem Matrices.Journal of analytical toxicology · 2022Article
- Article
- Morphine Accumulates in the Retina Following Chronic Systemic Administration.Pharmaceuticals (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitreous humor (VH) is a gelatinous substance contained in the posterior chamber of the eye, playing a mechanical role in the eyeball. It has been the subject of numerous studies in various forensic applications, primarily for the assessment of postmortem interval and for postmortem chemical analysis. Since most of the xenobiotics present in the bloodstream are detected in VH after crossing the selective blood-retinal barrier, VH is an alternative matrix useful for forensic toxicology. VH analysis offers particular advantages over other biological matrices: it is less prone to postmortem redistribution, is easy to collect, has relatively few interfering compounds for the analytical process, and shows sample stability over time after death. The present study is an overview of VH physiology, drug transport and elimination. Collection, storage, analytical techniques and interpretation of results from qualitative and quantitative points of view are dealt with. The distribution of xenobiotics in VH samples is thus discussed and illustrated by a table reporting the concentrations of 106 drugs from more than 300 case reports. For this purpose, a survey was conducted of publications found in the MEDLINE database from 1969 through April 30, 2015.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.