ArticleFrontiers in microbiology2015
Enterococcus faecalis from Food, Clinical Specimens, and Oral Sites: Prevalence of Virulence Factors in Association with Biofilm Formation.
Article in Frontiers in microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 3 of them syntheses that pooled it.
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Who cites it
104 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Association of virulence genes with biofilm formation in clinical Enterococcus faecalis isolates: a systematic review and meta-analysis.Archives of microbiology · 2026Pooled it
- Ciprofloxacin resistance in community and hospital-acquired urinary tract infections: a systematic review and meta-analysis from African population.BMC infectious diseases · 2025Pooled it
- The global prevalence of biofilm-forming Enterococcus faecalis in clinical isolates: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Gut microbial allies and adversaries in SARS-CoV-2 infection.Current research in microbial sciences · 2026Article
- 3-Hydroxyflavone Inhibits Biofilm Formation and Enhances Antibiotic Activity AgainstAntibiotics (Basel, Switzerland) · 2026Article
- Co-occurrence of biofilm formation, acid tolerance, and antibiotic resistance in environmental Escherichia coli associated with lettuce.BMC microbiology · 2026Article
- Prevalence, Molecular Characterisation and Antimicrobial Resistance ofPathogens (Basel, Switzerland) · 2026Article
- Sessile growth on human dentine is associated withJournal of conservative dentistry and endodontics · 2026Article
- Phenotypic and genotypic antimicrobial resistance profiles of gram-positive cocci and non-fermenting gram-negative rods.Scientific reports · 2026Article
- Tracking persistent and resistant Enterococcus faecalis and E. faecium from farm to fork: biofilm-linked risks in antibiotic resistance of isolates.Veterinary research communications · 2026Article
- Article
- Invasive guests: the role of non-oral bacteria in oral dysbiosis and systemic health.Journal of oral microbiology · 2026Review
- Article
- Synergistic interactions betweenProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exopolysaccharide (EPS)-ProducingFoods (Basel, Switzerland) · 2025Article
- Article
- Management of Enterococcus faecalis biofilms: a combinatorial approach with phytochemical.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Surfactin inhibits enterococcal biofilm formation via interference with pilus and exopolysaccharide biosynthesis.BMC microbiology · 2025Article
- Comprehensive analysis of bacteriocins produced by clinical enterococcal isolates and their antibacterial activity against Enterococci including VRE.Scientific reports · 2025Article
- Novel approaches on root canal disinfection methods againstJournal of oral microbiology · 2025Review
44 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enterococci have gained significance as the cause of nosocomial infections; they occur as food contaminants and have also been linked to dental diseases. E. faecalis has a great potential to spread virulence as well as antibiotic resistance genes via horizontal gene transfer. The integration of food-borne enterococci into the oral biofilm in-vivo has been observed. Therefore, we investigated the virulence determinants and antibiotic resistance of 97 E. faecalis isolates from the oral cavity, food, and clinical specimens. In addition, phenotypic expression of gelatinase and cytolysin were tested, in-vitro biofilm formation was quantified and isolates were compared for strain relatedness via pulsed field gel electrophoresis (PFGE). Each isolate was found to possess two or more virulence genes, most frequently gelE, efaA, and asa1. Notably, plaque/saliva isolates possessed the highest abundance of virulence genes, the highest levels of phenotypic gelatinase and hemolysin activity and concurrently a high ability to form biofilm. The presence of asa1 was associated with biofilm formation. The biofilm formation capacity of clinical and plaque/saliva isolates was considerably higher than that of food isolates and they also showed similar antibiotic resistance patterns. These results indicate that the oral cavity can constitute a reservoir for virulent E. faecalis strains possessing antibiotic resistance traits and at the same time distinct biofilm formation capabilities facilitating exchange of genetic material.
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