Evidence map›Paper›PMID 26793047›Full record

ArticleFrontiers in neuroscience2015

Neuroplastic Effects of Transcranial Direct Current Stimulation on Painful Symptoms Reduction in Chronic Hepatitis C: A Phase II Randomized, Double Blind, Sham Controlled Trial.

Aline P Brietzke, Joanna R Rozisky, Jairo A Dussan-Sarria, Alicia Deitos, Gabriela Laste, Priscila F T Hoppe, Suzana Muller, Iraci L S Torres, Mário R Alvares-da-Silva, Rivadavio F B de Amorim and 2 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  7. Non-invasive brain stimulation techniques for chronic pain.The Cochrane database of systematic reviews · 2018
    Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Aline P BrietzkeLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Joanna R RoziskyLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Jairo A Dussan-SarriaLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Alicia DeitosLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Gabriela LasteLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Priscila F T HoppeLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Suzana MullerLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Iraci L S TorresLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Mário R Alvares-da-SilvaDepartment of Internal Medicine (Gastroenterology/Hepatology), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Rivadavio F B de AmorimLaboratory of Neuromodulation and Center for Clinical Research Learning, Physics and Rehabilitation Department, Spaulding Rehabilitation Hospital Boston, MA, USA.
Felipe FregniLaboratory of Neuromodulation and Center for Clinical Research Learning, Physics and Rehabilitation Department, Spaulding Rehabilitation Hospital Boston, MA, USA.
Wolnei CaumoLaboratory of Pain and Neuromodulation, Department of Clinical Research Center, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul Porto Alegre, Brazil.
Hospital de Clínicas de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BRSpaulding Rehabilitation Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPegylated Interferon Alpha (Peg-IFN) in combination with other drugs is the standard treatment for chronic hepatitis C infection (HCV) and is related to severe painful symptoms. The aim of this study was access the efficacy of transcranial direct current stimulation (tDCS) in controlling the painful symptoms related to Peg-IFN side effects. MATERIALS AND

methodsIn this phase II double-blind trial, twenty eight (n = 28) HCV subjects were randomized to receive either 5 consecutive days of active tDCS (n = 14) or sham (n = 14) during 5 consecutive days with anodal stimulation over the primary motor cortex region using 2 mA for 20 min. The primary outcomes were visual analogue scale (VAS) pain and brain-derived neurotrophic factor (BDNF) serum levels. Secondary outcomes were the pressure-pain threshold (PPT), the Brazilian Profile of Chronic Pain: Screen (B-PCP:S), and drug analgesics use.

resultstDCS reduced the VAS scores (P < 0.003), with a mean pain drop of 56% (p < 0.001). Furthermore, tDCS was able to enhance BDNF levels (p < 0.01). The mean increase was 37.48% in the active group. Finally, tDCS raised PPT (p < 0.001) and reduced the B-PCP:S scores and analgesic use (p < 0.05).

conclusionsFive sessions of tDCS were effective in reducing the painful symptoms in HCV patients undergoing Peg-IFN treatment. These findings support the efficacy of tDCS as a promising therapeutic tool to improve the tolerance of the side effects related to the use of Peg-IFN. Future larger studies (phase III and IV trials) are needed to confirm the clinical use of the therapeutic effects of tDCS in such condition.

trial registrationBrazilian Human Health Regulator for Research with the approval number CAAE 07802012.0.0000.5327.

Indexed as

chronic painHepatitis CHepatitis C virusPEG-IFNtranscranial direct current stimulation

Identifiers

PMID26793047
PMCPMC4707227
OpenAlexW2253627989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.