ArticleFrontiers in neuroscience2015
Doublecortin (DCX) is not Essential for Survival and Differentiation of Newborn Neurons in the Adult Mouse Dentate Gyrus.
Article in Frontiers in neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Oxytocin enhances neurogenesis and synaptic plasticity to attenuate age-related cognitive decline in aged mice.IBRO neuroscience reports · 2025Article
- Adult human neurogenesis: A view from two schools of thought.IBRO neuroscience reports · 2023Review
- Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice.Molecular psychiatry · 2023Article
- Microtubule Organization Is Essential for Maintaining Cellular Morphology and Function.Oxidative medicine and cellular longevity · 2022Review
- HOP protein expression in the hippocampal dentate gyrus is acutely downregulated in a status epilepticus mouse model.IBRO neuroscience reports · 2021Article
- Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model.Molecular medicine reports · 2021Article
- No DCX-positive neurogenesis in the cerebral cortex of the adult primate.Neural regeneration research · 2020Article
- Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2.Scientific reports · 2018Article
- Stress and adolescent hippocampal neurogenesis: diet and exercise as cognitive modulators.Translational psychiatry · 2017Review
- Dioscin relieves endotoxemia induced acute neuro-inflammation and protect neurogenesis via improving 5-HT metabolism.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the adult brain, expression of the microtubule-associated protein Doublecortin (DCX) is associated with neural progenitor cells (NPCs) that give rise to new neurons in the dentate gyrus. Many studies quantify the number of DCX-expressing cells as a proxy for the level of adult neurogenesis, yet no study has determined the effect of removing DCX from adult hippocampal NPCs. Here, we use a retroviral and inducible mouse transgenic approach to either knockdown or knockout DCX from adult NPCs in the dentate gyrus and examine how this affects cell survival and neuronal maturation. Our results demonstrate that shRNA-mediated knockdown of DCX or Cre-mediated recombination in floxed DCX mice does not alter hippocampal neurogenesis and does not change the neuronal fate of the NPCs. Together these findings show that the survival and maturation of adult-generated hippocampal neurons does not require DCX.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.