Evidence map›Paper›PMID 26792888›Full record

ArticleJournal of neurophysiology2016

Ablation of the inferior olive prevents H-reflex down-conditioning in rats.

Xiang Yang Chen, Yu Wang, Yi Chen, Lu Chen, Jonathan R Wolpaw

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Xiang Yang ChenNational Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, New York; Department of Biomedical Sciences, State University of New York, Albany, New York; xiangyang.chen@health.ny.gov.
Yu WangNational Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, New York;
Yi ChenNational Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, New York;
Lu ChenNational Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, New York;
Jonathan R WolpawNational Center for Adaptive Neurotechnologies, Wadsworth Center, New York State Department of Health, Albany, New York; Department of Biomedical Sciences, State University of New York, Albany, New York; Department of Neurology, Albany Stratton Department of Veterans Affairs Medical Center, Albany, New York; and Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York.
New York State Department of Health · USAlbany State University · USUniversity at Albany, State University of New York · USWadsworth Center · US

Funding

SPINAL CIRCUITS &THE MUSCULOSKELETAL SYSTEMP01HD032571 · NICHD · EMORY UNIVERSITY · PI NICHOLS, T. RICHARD · 1995 to 2016
$16.2M
Training and DisseminationP41EB018783 · NIBIB · WADSWORTH CENTER · PI Jonathan Saul Carp · 2014 to 2026
$15.4M
SUPRASPINAL CONTROL OF SPINAL CORD PLASTICITYR01HD036020 · NICHD · WADSWORTH CENTER · PI CHEN, XIANG YANG · 1997 to 2012
$3.2M
ADAPTIVE PLASTICITY IN THE SPINAL STRETCH REFLEXR01NS022189 · NINDS · WADSWORTH CENTER · PI WOLPAW, JONATHAN RICKEL · 1985 to 2012
$3.1M
Spinal Reflex Conditioning and LocomotionR01NS061823 · NINDS · WADSWORTH CENTER · PI CHEN, XIANG YANG, WOLPAW, JONATHAN RICKEL · 2008 to 2011
$1.3M
BLRD VA I01 BX002550NIBIB NIH HHS 1P41 EB-018783NIBIB NIH HHS P41 EB018783NICHD NIH HHS HD-32571NICHD NIH HHS HD-36020NICHD NIH HHS P01 HD032571NICHD NIH HHS R01 HD036020NINDS NIH HHS NS-061823NINDS NIH HHS NS-22189NINDS NIH HHS R01 NS022189NINDS NIH HHS R01 NS061823
6 · The paper itself

Abstract

We evaluated the role of the inferior olive (IO) in acquisition of the spinal cord plasticity that underlies H-reflex down-conditioning, a simple motor skill. The IO was chemically ablated before a 50-day exposure to an operant conditioning protocol that rewarded a smaller soleus H-reflex. In normal rats, down-conditioning succeeds (i.e., H-reflex size decreases at least 20%) in 80% of animals. Down-conditioning failed in every IO-ablated rat (P< 0.001 vs. normal rats). IO ablation itself had no long-term effect on H-reflex size. These results indicate that the IO is essential for acquisition of a down-conditioned H-reflex. With previous data, they support the hypothesis that IO and cortical inputs to cerebellum enable the cerebellum to guide sensorimotor cortex plasticity that produces and maintains the spinal cord plasticity that underlies the down-conditioned H-reflex. They help to further define H-reflex conditioning as a model for understanding motor learning and as a new approach to enhancing functional recovery after trauma or disease.

Indexed as

Conditioning, ClassicalH-ReflexAnimalsCerebellumEvoked PotentialsMaleOlivary NucleusRatsRats, Sprague-DawleySpinal Cordcerebellumlearningoperant conditioningplasticityspinal cord

Identifiers

PMID26792888
PMCPMC4808093
OpenAlexW2300539019

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.