ArticleVeterinary pathology2016
The Vital Role of Pathology in Improving Reproducibility and Translational Relevance of Aging Studies in Rodents.
Article in Veterinary pathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- uPAR Immuno-PET in Pancreatic Cancer, Aging, and Chemotherapy-Induced Senescence.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024Article
- Canagliflozin retards age-related lesions in heart, kidney, liver, and adrenal gland in genetically heterogenous male mice.GeroScience · 2023Article
- Age and Sex Divergence in Hematopoietic Radiosensitivity in Aged Mouse Models of the Hematopoietic Acute Radiation Syndrome.Radiation research · 2022Article
- Dasatinib plus quercetin attenuates some frailty characteristics in SAMP10 mice.Scientific reports · 2022Article
- Development of Planar Illumination Strategies for Solving Mysteries in the Sub-Cellular Realm.International journal of molecular sciences · 2022Review
- Research-Relevant Conditions and Pathology of Laboratory Mice, Rats, Gerbils, Guinea Pigs, Hamsters, Naked Mole Rats, and Rabbits.ILAR journal · 2021Review
- Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration.Brain communications · 2020Article
- Histopathologic Evaluation and Scoring of Viral Lung Infection.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Validation of a geropathology grading system for aging mouse studies.GeroScience · 2019Article
- Fundamental Concepts for Semiquantitative Tissue Scoring in Translational Research.ILAR journal · 2018Article
- Pathology Principles and Practices for Analysis of Animal Models.ILAR journal · 2018Article
- Approaches to Evaluate Lung Inflammation in Translational Research.Veterinary pathology · 2018Review
- Spontaneous and Experimentally Induced Pathologies in the Naked Mole Rat (Heterocephalus glaber).Biochemistry. Biokhimiia · 2017Review
- Reproducibility of histopathological findings in experimental pathology of the mouse: a sorry tail.Lab animal · 2017Article
- How age, sex and genotype shape the stress response.Neurobiology of stress · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Pathology is a discipline of medicine that adds great benefit to aging studies of rodents by integrating in vivo, biochemical, and molecular data. It is not possible to diagnose systemic illness, comorbidities, and proximate causes of death in aging studies without the morphologic context provided by histopathology. To date, many rodent aging studies do not utilize end points supported by systematic necropsy and histopathology, which leaves studies incomplete, contradictory, and difficult to interpret. As in traditional toxicity studies, if the effect of a drug, dietary treatment, or altered gene expression on aging is to be studied, systematic pathology analysis must be included to determine the causes of age-related illness, moribundity, and death. In this Commentary, the authors discuss the factors that should be considered in the design of aging studies in mice, with the inclusion of robust pathology practices modified after those developed by toxicologic and discovery research pathologists. Investigators in the field of aging must consider the use of histopathology in their rodent aging studies in this era of integrative and preclinical geriatric science (geroscience).
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Registered trials
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