ArticleMolecular biology of the cell2016
Nanoscopic cell-wall architecture of an immunogenic ligand in Candida albicans during antifungal drug treatment.
Article in Molecular biology of the cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Microfluidic live-cell imaging of Aspergillus fumigatus and Candida albicans hyphal growth treated with AmBisome and Caspofungin.Journal of microscopy · 2026Article
- Revealing the ultrastructure of liveOpen biology · 2025Article
- Cell walls of filamentous fungi - challenges and opportunities for biotechnology.Applied microbiology and biotechnology · 2025Review
- Bayesian Inference of Binding Kinetics from Fluorescence Time Series.The journal of physical chemistry. B · 2025Article
- Fleagrass (Adenosma buchneroides Bonati) Acts as a Fungicide Against Candida albicans by Damaging Its Cell Wall.Journal of microbiology (Seoul, Korea) · 2024Article
- Dectin-1 multimerization and signaling depends on fungal β-glucan structure and exposure.Biophysical journal · 2023Article
- Use of red, far-red, and near-infrared light in imaging of yeasts and filamentous fungi.Applied microbiology and biotechnology · 2022Review
- K143R Amino Acid Substitution in 14-α-Demethylase (Erg11p) Changes Plasma Membrane and Cell Wall Structure ofInternational journal of molecular sciences · 2022Article
- Giardial lipid rafts share virulence factors with secreted vesicles and participate in parasitic infection in mice.Frontiers in cellular and infection microbiology · 2022Article
- Control of β-glucan exposure by the endo-1,3-glucanase Eng1 in Candida albicans modulates virulence.PLoS pathogens · 2022Article
- Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen,Pathogens (Basel, Switzerland) · 2021Review
- γ9δ2T cell diversity and the receptor interface with tumor cells.The Journal of clinical investigation · 2020Article
- Caspofungin Induced Cell Wall Changes ofFrontiers in cellular and infection microbiology · 2020Article
- Mannan detecting C-type lectin receptor probes recognise immune epitopes with diverse chemical, spatial and phylogenetic heterogeneity in fungal cell walls.PLoS pathogens · 2020Article
- β-1,3-glucan-lackingVirulence · 2019Article
- β-1,3-Glucan/CR3/SYK pathway-dependent LC3B-II accumulation enhanced the fungicidal activity in human neutrophils.Journal of microbiology (Seoul, Korea) · 2019Article
- Mannan Molecular Substructures Control Nanoscale Glucan Exposure in Candida.Cell reports · 2018Article
- Mechanisms of inside-out signaling of the high-affinity IgG receptor FcγRI.Science signaling · 2018Article
- Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.Trends in microbiology · 2018Review
- Titan cell production inCell surface (Amsterdam, Netherlands) · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The cell wall of Candida albicans is composed largely of polysaccharides. Here we focus on β-glucan, an immunogenic cell-wall polysaccharide whose surface exposure is often restricted, or "masked," from immune recognition by Dectin-1 on dendritic cells (DCs) and other innate immune cells. Previous research suggested that the physical presentation geometry of β-glucan might determine whether it can be recognized by Dectin-1. We used direct stochastic optical reconstruction microscopy to explore the fine structure of β-glucan exposed on C. albicans cell walls before and after treatment with the antimycotic drug caspofungin, which alters glucan exposure. Most surface-accessible glucan on C. albicans yeast and hyphae is limited to isolated Dectin-1-binding sites. Caspofungin-induced unmasking caused approximately fourfold to sevenfold increase in total glucan exposure, accompanied by increased phagocytosis efficiency of DCs for unmasked yeasts. Nanoscopic imaging of caspofungin-unmasked C. albicans cell walls revealed that the increase in glucan exposure is due to increased density of glucan exposures and increased multiglucan exposure sizes. These findings reveal that glucan exhibits significant nanostructure, which is a previously unknown physical component of the host-Candida interaction that might change during antifungal chemotherapy and affect innate immune activation.
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Registered trials
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