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ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Modifiable and non-modifiable risk factors affecting walking recovery after hip fracture.

G Pioli, F Lauretani, F Pellicciotti, P Pignedoli, C Bendini, M L Davoli, E Martini, A Zagatti, A Giordano, A Nardelli and 6 more

Abstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.

  1. Anabolic-steroid therapy after geriatric proximal femur fracture: a level I evidence systematic review and meta-analysis of bone density, functional recovery, and safety.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Pooled it
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  4. Pre-fracture functional status and 30-day recovery predict 5-year survival in patients with hip fracture: findings from a prospective real-world study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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  13. Preoperative severe vitamin D deficiency is a significant independent risk factor for poorer functional outcome and quality of life 6 months after surgery for fragility hip fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
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  18. Hip fracture patients admitted to hospital on weekends are not at increased risk of 30-day mortality as compared with weekdays.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

G PioliGeriatric Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Via Risorgimento 70, 42100, Reggio Emilia, Italy. giulio.pioli@asmn.re.it.
F LauretaniGeriatric Unit, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy.
F PellicciottiGeriatric Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Via Risorgimento 70, 42100, Reggio Emilia, Italy.
P PignedoliOrthopaedic Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Reggio Emilia, Italy.
C BendiniGeriatric Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Via Risorgimento 70, 42100, Reggio Emilia, Italy.
M L DavoliGeriatric Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Via Risorgimento 70, 42100, Reggio Emilia, Italy.
E MartiniOrthogeriatric Unit, Department of Internal Medicine, Aging and Nephrology, University Hospital Policlinico S.Orsola Malpighi, Bologna, Italy.
A ZagattiOrthogeriatric Unit, S. Anna Hospital, Ferrara, Italy.
A GiordanoGeriatric Unit, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy.
A NardelliGeriatric Unit, Geriatric-Rehabilitation Department, University Hospital of Parma, Parma, Italy.
A ZurloOrthogeriatric Unit, S. Anna Hospital, Ferrara, Italy.
D BianchiniPhysical and Rehabilitation Medicine Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Reggio Emilia, Italy.
E SabettaOrthopaedic Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Reggio Emilia, Italy.
A FerrariGeriatric Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Via Risorgimento 70, 42100, Reggio Emilia, Italy.
C TedeschiPhysical and Rehabilitation Medicine Unit, Department of Neuromotor Physiology, ASMN-IRCCS, Reggio Emilia, Italy.
M L LunardelliOrthogeriatric Unit, Department of Internal Medicine, Aging and Nephrology, University Hospital Policlinico S.Orsola Malpighi, Bologna, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITUniversity of Parma · ITOspedale Sant'Anna · ITPoliclinico S.Orsola-Malpighi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledModifiable and non-modifiable predictors of mobility recovery were analyzed on a sample of 774 hip fracture patients according to pre-fracture abilities. Overall predictors were mostly non-modifiable factors related to frailty of patients with the exception of 25-hydroxyvitamin D concentration which significantly affected walking recovery, especially in patients with higher pre-fracture performance.

introductionThis study aims to investigate mobility changes after hip fracture with the aim of identifying modifiable and non-modifiable predictors of mobility recovery according to different pre-fracture abilities.

methodsThis is a prospective inception cohort study of consecutive older patients, admitted with a fragility hip fracture in three Hospitals of Emilia Romagna (Italy). A sample of 774 patients alive at the sixth month was divided into three groups according to pre-fracture ambulation ability (group 1: mobile outdoors; group 2: mobile indoors; and group 3: mobile with help). The relationship between baseline characteristics of patients and the odds of walking recovery was analyzed using multivariate regression analysis.

resultsMortality differed significantly among the three groups and was the highest in patients needing help to walk. Among the survivors, only 50.3 % of patients recovered walking ability. In a multivariate analysis, independent risk factors were different among the three groups. In group 1, older age, comorbidities, the use of walking devices before fracture, and low albumin level acted as negative factors while male gender, a pre-fracture high functional status, and higher 25-hydroxyvitamin D levels increased the probability of full recovery. In group 2, only pre-fracture functional status and 25-hydroxyvitamin D concentration were related to the recovery of walking ability. Pre-fracture functional status was also the only significant predictor for patients in group 3.

conclusionsSeveral baseline characteristics of patients are related to the likelihood of recovering walking ability after hip fracture. The 25-hydroxyvitamin D level seems to be the only relevant modifiable factor even if the effectiveness of its supplementation has yet to be demonstrated.

Indexed as

Recovery of FunctionWalkingActivities of Daily LivingAgedAged, 80 and overFemaleHip FracturesHumansItalyMaleProspective StudiesRisk FactorsVitamin D25-hydroxyvitamin DVitamin DCognitive impairmentElderlyFunctional statusHip fractureVitamin DWalking recovery

Identifiers

PMID26792647
OpenAlexW2276818077

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.