ArticleScientific reports2016
c.A2456C-substitution in Pck1 changes the enzyme kinetic and functional properties modifying fat distribution in pigs.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Identification of breed-specific genomic variants in Colombian Creole pig breeds by whole-genome sequencing.Tropical animal health and production · 2023Article
- Proteomic and clinical biomarkers for acute mountain sickness in a longitudinal cohort.Communications biology · 2022Article
- Transcriptional Insights into Key Genes and Pathways Underlying Muscovy Duck Subcutaneous Fat Deposition at Different Developmental Stages.Animals : an open access journal from MDPI · 2021Article
- Adipose Tissue Gene Expression of Entire Male, Immunocastrated and Surgically Castrated Pigs.International journal of molecular sciences · 2021Article
- Comparative transcriptome analysis reveals that PCK1 is a potential gene affecting IMF deposition in buffalo.BMC genomics · 2020Article
- Comparative Transcriptomic Analysis of Subcutaneous Adipose Tissue from Local Pig Breeds.Genes · 2020Article
- pCADD: SNV prioritisation in Sus scrofa.Genetics, selection, evolution : GSE · 2020Article
- Article
- Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions.Molecular cell · 2018Article
- A genome-wide association study of growth and fatness traits in two pig populations with different genetic backgrounds.Journal of animal science · 2018Article
- Article
- O-GlcNAcylation mediates the control of cytosolic phosphoenolpyruvate carboxykinase activity via Pgc1α.PloS one · 2017Article
- Genetic Marker Discovery in Complex Traits: A Field Example on Fat Content and Composition in Pigs.International journal of molecular sciences · 2016Review
- Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase.Biochemistry and biophysics reports · 2016Article
- Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors.PloS one · 2016Article
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6 authors.
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Abstract
Cytosolic phosphoenolpyruvate carboxykinase, PCK1, is one of the main regulatory enzymes of gluconeogenesis and glyceroneogenesis. The substitution of a single amino acid (Met139Leu) in PCK1 as a consequence of a single nucleotide polymorphism (SNP), c.A2456C, is associated in the pig to a negative phenotype characterized by reduced intramuscular fat content, enhanced backfat thickness and lower meat quality. The p.139L enzyme shows reduced kcat values in the glyceroneogenic direction and enhanced ones in the anaplerotic direction. Accordingly, the expression of the p.139L isoform results in about 30% lower glucose and 9% lower lipid production in cell cultures. Moreover, the ability of this isoform to be acetylated is also compromised, what would increase its susceptibility to be degraded in vivo by the ubiquitin-proteasome system. The high frequency of the c.2456C allele in modern pig breeds implies that the benefits of including c.A2456C SNP in selection programs could be considerable.
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