Evidence map›Paper›PMID 26792214›Full record

ArticleBMJ open2016

Anthropometric markers and their association with incident type 2 diabetes mellitus: which marker is best for prediction? Pooled analysis of four German population-based cohort studies and comparison with a nationwide cohort study.

Saskia Hartwig, Alexander Kluttig, Daniel Tiller, Julia Fricke, Grit Müller, Sabine Schipf, Henry Völzke, Michaela Schunk, Christa Meisinger, Anja Schienkiewitz and 8 more

Abstract read
In one paragraph

Article in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  19. Comparison of Body Mass Index and Waist Circumference in the Prediction of Diabetes: A Retrospective Longitudinal Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Saskia HartwigInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Alexander KluttigInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany German Center for Diabetes Research (DZD), München-Neuherberg, Germany.
Daniel TillerInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Julia FrickeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany Institute for Social Medicine, Epidemiology and Health Economics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Grit MüllerInstitute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany.
Sabine SchipfGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Henry VölzkeGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Michaela SchunkInstitute of Health Economics and Health Care Management, Helmholtz Zentrum München, Neuherberg, Germany.
Christa MeisingerGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany.
Anja SchienkiewitzDepartment of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
Christin HeidemannDepartment of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
Susanne MoebusInstitute for Medical Informatics, Biometry, and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Sonali PechlivanisInstitute for Medical Informatics, Biometry, and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.
Karl WerdanDepartment of Medicine III, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Oliver KussGerman Center for Diabetes Research (DZD), München-Neuherberg, Germany Institute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.
Teresa TamayoInstitute of Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine-University, Düsseldorf, Germany.
Johannes HaertingInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Karin Halina GreiserInstitute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany German Center for Diabetes Research (DZD), München-Neuherberg, Germany Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo compare the association between different anthropometric measurements and incident type 2 diabetes mellitus (T2DM) and to assess their predictive ability in different regions of Germany.

methodsData of 10,258 participants from 4 prospective population-based cohorts were pooled to assess the association of body weight, body mass index (BMI), waist circumference (WC), waist-to-hip-ratio (WHR) and waist-to-height-ratio (WHtR) with incident T2DM by calculating HRs of the crude, adjusted and standardised markers, as well as providing receiver operator characteristic (ROC) curves. Differences between HRs and ROCs for the different anthropometric markers were calculated to compare their predictive ability. In addition, data of 3105 participants from the nationwide survey were analysed separately using the same methods to provide a nationally representative comparison.

resultsStrong associations were found for each anthropometric marker and incidence of T2DM. Among the standardised anthropometric measures, we found the strongest effect on incident T2DM for WC and WHtR in the pooled sample (HR for 1 SD difference in WC 1.97, 95% CI 1.75 to 2.22, HR for WHtR 1.93, 95% CI 1.71 to 2.17 in women) and in female DEGS participants (HR for WC 2.24, 95% CI 1.91 to 2.63, HR for WHtR 2.10, 95% CI 1.81 to 2.44), whereas the strongest association in men was found for WHR among DEGS participants (HR 2.29, 95% CI 1.89 to 2.78). ROC analysis showed WHtR to be the strongest predictor for incident T2DM. Differences in HR and ROCs between the different markers confirmed WC and WHtR to be the best predictors of incident T2DM. Findings were consistent across study regions and age groups (<65 vs ≥ 65 years).

conclusionsWe found stronger associations between anthropometric markers that reflect abdominal obesity (ie, WC and WHtR) and incident T2DM than for BMI and weight. The use of these measurements in risk prediction should be encouraged.

Indexed as

AnthropometryBody Mass IndexBody WeightCohort StudiesComorbidityDiabetes Mellitus, Type 2FemaleGermanyHumansIncidenceMaleMiddle AgedObesity, AbdominalWaist CircumferenceWaist-Height RatioWaist-Hip RatioEPIDEMIOLOGYPUBLIC HEALTH

Identifiers

PMID26792214
PMCPMC4735317

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.