Evidence map›Paper›PMID 26792050›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2016

Cocaine-induced Psychosis and Brain-derived Neurothrophic Factor in Patients with Cocaine Dependence: Report of Two Cases.

Carlos Roncero, Raul Felipe Palma-Álvarez, Elena Ros-Cucurull, Carmen Barral, Begoña Gonzalvo, Margarida Corominas-Roso, Miguel Casas, Lara Grau-López

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PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carlos RonceroAddictions and Dual Diagnosis Unit, Vall d'Hebron University Hospital-Public Health Agency of Barcelona (ASPB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Raul Felipe Palma-ÁlvarezDepartment of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Spain.
Elena Ros-CucurullAddictions and Dual Diagnosis Unit, Vall d'Hebron University Hospital-Public Health Agency of Barcelona (ASPB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Carmen BarralAddictions and Dual Diagnosis Unit, Vall d'Hebron University Hospital-Public Health Agency of Barcelona (ASPB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Begoña GonzalvoDepartment of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Spain.
Margarida Corominas-RosoDepartment of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Spain.
Miguel CasasDepartment of Psychiatry, Vall d'Hebron University Hospital, CIBERSAM, Spain.
Lara Grau-LópezAddictions and Dual Diagnosis Unit, Vall d'Hebron University Hospital-Public Health Agency of Barcelona (ASPB), Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.
Vall d'Hebron Hospital Universitari · ESCentro de Investigación Biomédica en Red de Salud Mental · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is linked to numerous brain functions. In addition, BDNF alterations contribute to neurological, mental, and addictive disorders. Cocaine dependence has received much attention recently due to its prevalence and psychological effects. Symptoms of psychosis are one of the most serious adverse events precipitated by cocaine use. It is particularly important to identify patients at risk of developing cocaine-induced psychosis (CIP). We described two cases of patients with cocaine dependence who presented with CIP and had changes in their BDNF levels during the psychotic episode. BDNF levels were initially low in both patients, and then decreased by more than 50% in association with CIP. The relationship between BDNF and psychosis is described in the literature. These cases revealed that BDNF levels decreased during a CIP episode and, thus, it is necessary to investigate BDNF and its relationship with CIP further.

Indexed as

Biological markerBrain-derived neurotrophic factorCocaine dependenceinduced psychosisPsychosis

Identifiers

PMID26792050
PMCPMC4730925
OpenAlexW2331259721

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.