Evidence map›Paper›PMID 26792036›Full record

ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2016

Therapeutic Misconception in Psychiatry Research: A Systematic Review.

Ivan Sk Thong, Meng Yee Foo, Min Yi Sum, Benjamin Capps, Tih-Shih Lee, Calvin Ho, Kang Sim

Open access · diamondAbstract read
In one paragraph

Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. Therapeutic Misconception as a Problem of Nonmaleficence by Way of False Hope.Health care analysis : HCA : journal of health philosophy and policy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ivan Sk ThongThe College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA.
Meng Yee FooThe College of Arts and Sciences, University at Buffalo, Buffalo, New York, USA.
Min Yi SumResearch Division, Institute of Mental Health, Singapore, Singapore.
Benjamin CappsDepartment of Bioethics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Tih-Shih LeeDuke-NUS Graduate Medical School, Singapore, Singapore.
Calvin HoCentre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Kang SimResearch Division, Institute of Mental Health, Singapore, Singapore.
Institute of Mental Health · SGDalhousie University · CADuke-NUS Medical School · SGNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Therapeutic misconception (TM) denotes the phenomenon in which research subjects conflate research purpose, protocols and procedures with clinical treatment. We examined the prevalence, contributory factors, clinical associations, impact, and collated solutions on TM within psychiatric research, and made suggestions going ahead. Literature search for relevant empirical research papers was conducted until February 2015. Eighty-eight reports were extracted, of which 31 were selected, summarised into different headings for discussion of implications and collated solutions of TM. We found variable and high rates of TM (ranging from 12.5% to 86%) in some psychiatry research populations. Contributory factors to TM included perceived medical roles of researchers, media, research setting and subject factors. Greater TM in affective, neurodevelopmental and psychotic spectrum conditions were associated with demographic variables (such as lower education, increased age), clinical factors (such as poor insight, cognitive deficits, increased symptoms, poorer self-rated quality of health), and social functioning (such as decreased independence). Inattention to TM may lead to frustration, negative impression and abandonment of participation in psychiatry research. Strategies such as the employment of a neutral educator during the informed consent process and education modules may be effective in addressing TM. Further research is warranted to examine the different TM facets, specific clinical correlates and more effective management strategies.

Indexed as

Affective disordersPsychiatrypsychoticResearchTherapeutic misconception

Identifiers

PMID26792036
PMCPMC4730932
OpenAlexW2256276693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.