ArticleClinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology2016
Cognitive Deficits as a Mediator of Poor Occupational Function in Remitted Major Depressive Disorder Patients.
Article in Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03620253 (Does Modafinil Have Pro-cognitive Effects in Those With Residual Cognitive Impairment Despite Remitted Depression?), which is not on this map. Cited by 78 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Does Modafinil Have Pro-cognitive Effects in Those With Residual Cognitive Impairment Despite Remitted Depression?
Who cites it
78 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Change in Cognitive Function over the Course of Major Depressive Disorder: A Systematic Review and Meta-analysis.Neuropsychology review · 2025Pooled it
- Effects of Transcranial Direct Current Stimulation on Cognitive Deficits in Depression: A Systematic Review.Psychiatry and clinical psychopharmacology · 2023Pooled it
- Effectiveness of cognitive remediation in subjects with major depressive disorder: A multicenter randomized controlled study in a real-world setting.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Cognitive function after electroconvulsive therapy for depression: relationship to clinical response.Psychological medicine · 2021Trial
- Trial
- Effects of levomilnacipran extended-release on major depressive disorder patients with cognitive impairments: post-hoc analysis of a phase III study.International clinical psychopharmacology · 2017Trial
- Towards precision psychiatry: initial foundations and future directions.Nature reviews. Drug discovery · 2026Review
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Predicting weekly instability in depressive symptoms among individuals diagnosed with Major Depressive Disorder using deep learning and passively-collected movement data.Journal of affective disorders reports · 2026Article
- Link Between Anhedonia, Reward Dysfunction, and Eating Behavior Across Mental and Physical Health Conditions: A Narrative Review.Nutrients · 2026Review
- A Secondary Analysis of Longitudinal Pilot-Study Data Investigating the Associations Between Health-Related Quality of Life and Executive Functions in Remitted Major Depressive Disorder and Developments Two-Years Following Cognitive Training.Scandinavian journal of psychology · 2026Article
- Korean Medication Algorithm Project for Depressive Disorder 2025: Comparisons with Other Treatment Guidelines.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Review
- Occupational therapists' perceived ability to facilitate reasonable accommodations in the workplace for employees with major depressive disorders.African journal of disability · 2026Article
- Long-term occupational outcomes in major depressive disorder: a 10-year follow-up study of symptom and comorbidity predictors.BMC psychiatry · 2025Article
- Exploring risky decision-making dynamics during antidepressant treatment in major depressive disorder: a computational modeling approach.BMC psychiatry · 2025Article
- Neurocognitive dysfunction in adolescents with recent onset major depressive disorder: a cross-sectional comparative study.European child & adolescent psychiatry · 2025Article
- Considering Theory-Based Gamification in the Co-Design and Development of a Virtual Reality Cognitive Remediation Intervention for Depression (bWell-D): Mixed Methods Study.JMIR serious games · 2025Article
- Long-Term Cognitive Outcomes of Esketamine Nasal Spray in Treatment-Resistant Depression: A Preliminary Report.Pharmaceuticals (Basel, Switzerland) · 2025Article
- A case study on using quantile regression in psychiatry research.Frontiers in psychiatry · 2025Article
- Parsing the heterogeneity of depression: a data-driven subgroup derived from cognitive function.Frontiers in psychiatry · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive deficits in major depressive disorder (MDD) patients have been described in numerous studies. However, few reports have aimed to describe cognitive deficits in the remitted state of MDD and the mediational effect of cognitive deficits on occupational outcome. The aim of the current review is to synthesize the literature on the mediating and moderating effects of specific domains of cognition on occupational impairment among people with remitted MDD. In addition, predictors of cognitive deficits found to be vocationally important will be examined. Upon examination of the extant literature, attention, executive function and verbal memory are areas of consistent impairment in remitted MDD patients. Cognitive domains shown to have considerable impact on vocational functioning include deficits in memory, attention, learning and executive function. Factors that adversely affect cognitive function related to occupational accommodation include higher age, late age at onset, residual depressive symptoms, history of melancholic/psychotic depression, and physical/psychiatric comorbidity, whereas higher levels of education showed a protective effect against cognitive deficit. Cognitive deficits are a principal mediator of occupational impairment in remitted MDD patients. Therapeutic interventions specifically targeting cognitive deficits in MDD are needed, even in the remitted state, to improve functional recovery, especially in patients who have a higher risk of cognitive deficit.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.