ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
SGLT1 sugar transporter/sensor is required for post-oral glucose appetition.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- A lateralized pathway for associating nutrients with flavors.bioRxiv : the preprint server for biology · 2025Article
- Sugar type and route of delivery influence insulin and glucose-dependent insulinotropic polypeptide responses in rats.American journal of physiology. Endocrinology and metabolism · 2025Article
- Gustatory and olfactory-guided responsiveness to maltodextrin solutions in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- Rewiring the Brain Through the Gut: Insights into Microbiota-Nervous System Interactions.Current issues in molecular biology · 2025Review
- Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.bioRxiv : the preprint server for biology · 2023Article
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- Article
- Intestinal plasticity and metabolism as regulators of organismal energy homeostasis.Nature metabolism · 2022Review
- The neural basis of sugar preference.Nature reviews. Neuroscience · 2022Review
- Internal senses of the vagus nerve.Neuron · 2022Review
- Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis.Nutrients · 2021Review
- Learning of food preferences: mechanisms and implications for obesity & metabolic diseases.International journal of obesity (2005) · 2021Review
- Monitoring In Vivo Neural Activity to Understand Gut-Brain Signaling.Endocrinology · 2021Review
- Genetics of mouse behavioral and peripheral neural responses to sucrose.Mammalian genome : official journal of the International Mammalian Genome Society · 2021Article
- Hypothalamic detection of macronutrients via multiple gut-brain pathways.Cell metabolism · 2021Article
- Viscera affectum anno: the gut beyond eating behaviours.Nature reviews. Gastroenterology & hepatology · 2021Review
- Sweet Taste Is Complex: Signaling Cascades and Circuits Involved in Sweet Sensation.Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Recent findings suggest that the intestinal sodium-glucose transporter 1 (SGLT1) glucose transporter and sensor mediates, in part, the appetite-stimulation actions of intragastric (IG) glucose and nonmetabolizable α-methyl-d-glucopyranoside (MDG) infusions in mice. Here, we investigated the role of SGLT1 in sugar conditioning using SGLT1 knockout (KO) and C57BL/6J wild-type (WT) mice. An initial experiment revealed that both KO and WT mice maintained on a very low-carbohydrate diet display normal preferences for saccharin, which was used in the flavored conditioned stimulus (CS) solutions. In experiment 2, mice were trained to drink one flavored solution (CS+) paired with an IG MDG infusion and a different flavored solution (CS-) paired with IG water infusion. In contrast to WT mice, KO mice decreased rather than increased the intake of the CS+ during training and failed to prefer the CS+ over the CS- in a choice test. In experiment 3, the KO mice also decreased their intake of a CS+ paired with IG glucose and avoided the CS+ in a choice test, unlike WT mice, which preferred the CS+ to CS-. In experiment 4, KO mice, like WT mice preferred a glucose + saccharin solution to a saccharin solution. These findings support the involvement of SGLT1 in post-oral glucose and MDG conditioning. The results also indicate that sugar malabsorption in KO mice has inhibitory effects on sugar intake but does not block their natural preference for sweet taste.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.