ArticleNature communications2016
Pin1At regulates PIN1 polar localization and root gravitropism.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 70 citations in OpenAlex.
- Plant Regeneration: Influencing Factors, Regulatory Networks, and Epigenetic Mechanisms.International journal of molecular sciences · 2026Review
- Deciphering the Protein Phosphorylation Dynamics Triggered by Seconds of Force Stimulation.Molecular & cellular proteomics : MCP · 2026Article
- SMXL3 controls multiple aspects of Arabidopsis development via EAR motif-dependent and -independent functions.The Plant journal : for cell and molecular biology · 2026Article
- Pin1-catalyzed conformational regulation after phosphorylation: A distinct checkpoint in cell signaling and drug discovery.Science signaling · 2024Review
- Mapping the membrane orientation of auxin homeostasis regulators PIN5 and PIN8 in Arabidopsis thaliana root cells reveals their divergent topology.Plant methods · 2024Article
- Molecular mechanism of brassinosteroids involved in root gravity response based on transcriptome analysis.BMC plant biology · 2024Article
- Article
- The prolyl isomerase Pin1 stabilizes NeuroD during differentiation of mechanoreceptors.Frontiers in cell and developmental biology · 2023Article
- WAVY GROWTH Arabidopsis E3 ubiquitin ligases affect apical PIN sorting decisions.Nature communications · 2022Article
- The Hydrophilic Loop ofInternational journal of molecular sciences · 2022Article
- Optimized synthesis of layered double hydroxide lactate nanosheets and their biological effects on Arabidopsis seedlings.Plant methods · 2022Article
- Auxin Transporters-A Biochemical View.Cold Spring Harbor perspectives in biology · 2022Review
- The kingdom of the prolyl-isomerase Pin1: The structural and functional convergence and divergence of Pin1.Frontiers in cell and developmental biology · 2022Review
- Morphological, phenological, and transcriptional analyses provide insight into the diverse flowering traits of a mutant of the relic woody plant Liriodendron chinense.Horticulture research · 2021Article
- The Protein Phosphatase PP2A Plays Multiple Roles in Plant Development by Regulation of Vesicle Traffic-Facts and Questions.International journal of molecular sciences · 2021Review
- A Retro-Perspective on Auxin Transport.Frontiers in plant science · 2021Article
- A Redox-Sensitive Cysteine Is Required for PIN1At Function.Frontiers in plant science · 2021Article
- WUSCHEL-related homeobox1 (WOX1) regulates vein patterning and leaf size in Cucumis sativus.Horticulture research · 2020Article
- Auxin-transporting ABC transporters are defined by a conserved D/E-P motif regulated by a prolylisomerase.The Journal of biological chemistry · 2020Article
- Genome-Wide Analysis of the PIN Auxin Efflux Carrier Gene Family in Coffee.Plants (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Root gravitropism allows plants to establish root systems and its regulation depends on polar auxin transport mediated by PIN-FORMED (PIN) auxin transporters. PINOID (PID) and PROTEIN PHOSPHATASE 2A (PP2A) act antagonistically on reversible phosphorylation of PINs. This regulates polar PIN distribution and auxin transport. Here we show that a peptidyl-prolyl cis/trans isomerase Pin1At regulates root gravitropism. Downregulation of Pin1At suppresses root agravitropic phenotypes of pp2aa and 35S:PID, while overexpression of Pin1At affects root gravitropic responses and enhances the pp2aa agravitropic phenotype. Pin1At also affects auxin transport and polar localization of PIN1 in stele cells, which is mediated by PID and PP2A. Furthermore, Pin1At catalyses the conformational change of the phosphorylated Ser/Thr-Pro motifs of PIN1. Thus, Pin1At mediates the conformational dynamics of PIN1 and affects PID- and PP2A-mediated regulation of PIN1 polar localization, which correlates with the regulation of root gravitropism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.