Evidence map›Paper›PMID 26791749›Full record

ArticleScientific reports2016

Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans.

Slavica Berber, Mallory Wood, Estelle Llamosas, Priya Thaivalappil, Karen Lee, Bing Mana Liao, Yee Lian Chew, Aaron Rhodes, Duygu Yucel, Merlin Crossley and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Loss ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. HIPK2 in the physiology of nervous system and its implications in neurological disorders.Biochimica et biophysica acta. Molecular cell research · 2023
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Slavica BerberSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Mallory WoodSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Estelle LlamosasSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Priya ThaivalappilSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Karen LeeSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Bing Mana LiaoSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Yee Lian ChewSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Aaron RhodesSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Duygu YucelSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
Merlin CrossleySchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, Australia.
Hannah R NicholasSchool of Molecular Bioscience, University of Sydney, Sydney, Australia.
University of Sydney · AUUNSW Sydney · AU

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Proteins of the Homeodomain-Interacting Protein Kinase (HIPK) family regulate an array of processes in mammalian systems, such as the DNA damage response, cellular proliferation and apoptosis. The nematode Caenorhabditis elegans has a single HIPK homologue called HPK-1. Previous studies have implicated HPK-1 in longevity control and suggested that this protein may be regulated in a stress-dependent manner. Here we set out to expand these observations by investigating the role of HPK-1 in longevity and in the response to heat and oxidative stress. We find that levels of HPK-1 are regulated by heat stress, and that HPK-1 contributes to survival following heat or oxidative stress. Additionally, we show that HPK-1 is required for normal longevity, with loss of HPK-1 function leading to a faster decline of physiological processes that reflect premature ageing. Through microarray analysis, we have found that HPK-1-regulated genes include those encoding proteins that serve important functions in stress responses such as Phase I and Phase II detoxification enzymes. Consistent with a role in longevity assurance, HPK-1 also regulates the expression of age-regulated genes. Lastly, we show that HPK-1 functions in the same pathway as DAF-16 to regulate longevity and reveal a new role for HPK-1 in development.

Indexed as

Gene Expression RegulationAgingAnimalsCaenorhabditis elegansGene Knockout TechniquesHeat-Shock ResponseInsulinInsulin-Like Growth Factor IIntestinal MucosaLongevityOxidative StressProtein Serine-Threonine KinasesSignal TransductionStress, Physiologicalhematopoietic progenitor kinase 1InsulinInsulin-Like Growth Factor IProtein Serine-Threonine Kinases

Identifiers

PMID26791749
PMCPMC4726358
OpenAlexW2268034957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.