Evidence map›Paper›PMID 26791565›Full record

ReviewJournal of translational medicine2016

Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation?

T C Saat, E K van den Akker, J N M IJzermans, F J M F Dor, R W F de Bruin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. Preclinical models versus clinical renal ischemia reperfusion injury: A systematic review based on metabolic signatures.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

T C SaatDepartment of Surgery, Erasmus MC, University Medical Center, Room Ee-100, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. t.saat@erasmusmc.nl.
E K van den AkkerDepartment of Surgery, Erasmus MC, University Medical Center, Room Ee-100, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. ekvandenakker@gmail.com.
J N M IJzermansDepartment of Surgery, Erasmus MC, University Medical Center, Room Ee-100, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. j.ijzermans@erasmusmc.nl.
F J M F DorDepartment of Surgery, Erasmus MC, University Medical Center, Room Ee-100, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. f.dor@erasmusmc.nl.
R W F de BruinDepartment of Surgery, Erasmus MC, University Medical Center, Room Ee-100, Dr. Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands. debruin@erasmusmc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kidney transplantation is the treatment of choice in patients with end stage renal disease. During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor for acute kidney injury, delayed graft function and acute and chronic rejection. Kidneys from living donors show a superior short- and long-term graft survival compared with deceased donors. However, the shortage of donor kidneys has resulted in expansion of the donor pool by using not only living- and brain death donors but also kidneys from donation after circulatory death and from extended criteria donors. These grafts are associated with an increased sensitivity to IRI and decreased graft outcome due to prolonged ischemia and donor comorbidity. Therefore, preventing or ameliorating IRI may improve graft survival. Animal experiments focus on understanding the mechanism behind IRI and try to find methods to minimize IRI either before, during or after ischemia. This review evaluates the different experimental strategies that have been investigated to prevent or ameliorate renal IRI. In addition, we review the current state of translation to the clinical setting. Experimental research has contributed to the development of strategies to prevent or ameliorate IRI, but promising results in animal studies have not yet been successfully translated to clinical use.

Indexed as

Kidney TransplantationTranslational Research, BiomedicalAnimalsHumansIschemiaKidneyReperfusion InjuryTreatment Outcome

Identifiers

PMID26791565
PMCPMC4721068

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.