ArticleHistochemistry and cell biology2016
Tissue-of-origin-specific gene repositioning in breast and prostate cancer.
Article in Histochemistry and cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Chromosome territory reorganization through artificial chromosome fusion is compatible with cell fate determination and mouse development.Cell discovery · 2023Article
- Nuclear position modulates long-range chromatin interactions.PLoS genetics · 2022Article
- Alterations to Genome Organisation in Stem Cells, Their Differentiation and Associated Diseases.Results and problems in cell differentiation · 2022Article
- Interactions Between Nucleosomes: From Atomistic Simulation to Polymer Model.Frontiers in molecular biosciences · 2021Article
- Molecular basis and biological function of variability in spatial genome organization.Science (New York, N.Y.) · 2019Review
- Article
- Assessment of the Utility of Gene Positioning Biomarkers in the Stratification of Prostate Cancers.Frontiers in genetics · 2019Article
- Topokaryotyping demonstrates single cell variability and stress dependent variations in nuclear envelope associated domains.Nucleic acids research · 2018Article
- Blank spots on the map: some current questions on nuclear organization and genome architecture.Histochemistry and cell biology · 2018Review
- The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases.PLoS neglected tropical diseases · 2018Article
- Emerin modulates spatial organization of chromosome territories in cells on softer matrices.Nucleic acids research · 2018Article
- Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.Methods (San Diego, Calif.) · 2017Article
- Genome Architecture from a Different Angle.Developmental cell · 2017Article
- The emerging landscape ofF1000Research · 2017Review
- Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms.Molecular biology of the cell · 2016Article
- In focus in Vienna: the cell nucleus.Histochemistry and cell biology · 2016Article
- Spatial Genome Organization and Its Emerging Role as a Potential Diagnosis Tool.Frontiers in genetics · 2016Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Genes have preferential non-random spatial positions within the cell nucleus. The nuclear position of a subset of genes differ between cell types and some genes undergo repositioning events in disease, including cancer. It is currently unclear whether the propensity of a gene to reposition reflects an intrinsic property of the locus or the tissue. Using quantitative FISH analysis of a set of genes which reposition in cancer, we test here the tissue specificity of gene repositioning in normal and malignant breast or prostate tissues. We find tissue-specific organization of the genome in normal breast and prostate with 40 % of genes occupying differential positions between the two tissue types. While we demonstrate limited overlap between gene sets that repositioned in breast and prostate cancer, we identify two genes that undergo disease-related gene repositioning in both cancer types. Our findings indicate that gene repositioning in cancer is tissue-of-origin specific.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.