ArticleRadiation and environmental biophysics2016
In vitro RABiT measurement of dose rate effects on radiation induction of micronuclei in human peripheral blood lymphocytes.
Article in Radiation and environmental biophysics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Review
- Continuous βClinical and translational radiation oncology · 2025Article
- X-ray and DNA Damage: Limitations of the Dose as a Parameter for In Vitro Studies.International journal of molecular sciences · 2023Article
- Sex and dose rate effects in automated cytogenetics.Radiation protection dosimetry · 2023Article
- Variable Dose Rates in Realistic Radiation Exposures: Effects on Small Molecule Markers of Ionizing Radiation in the Murine Model.Radiation research · 2023Article
- Validation of a High-Throughput Dicentric Chromosome Assay Using Complex Radiation Exposures.Radiation research · 2023Article
- Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility.Scientific reports · 2022Article
- A machine learning method for improving the accuracy of radiation biodosimetry by combining data from the dicentric chromosomes and micronucleus assays.Scientific reports · 2022Article
- Transcriptomics of Wet Skin Biopsies Predict Early Radiation-Induced Hematological Damage in a Mouse Model.Genes · 2022Article
- Challenges and Strategies in the Development of Radiation Biodosimetry Tests for Patient Management.Radiation research · 2021Review
- VADER: a variable dose-rate externalScientific reports · 2020Article
- Physical Exercise and Immune System in the Elderly: Implications and Importance in COVID-19 Pandemic Period.Frontiers in psychology · 2020Review
- RABiT-II: A Fully-Automated Micronucleus Assay System with Shortened Time to Result.Radiation research · 2019Article
- The first in vivo multiparametric comparison of different radiation exposure biomarkers in human blood.PloS one · 2018Article
- Article
- Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer.Radiation and environmental biophysics · 2017Article
- Mice and the A-Bomb: Irradiation Systems for Realistic Exposure Scenarios.Radiation research · 2017Article
- Biomarkers of Ionizing Radiation Exposure: A Multiparametric Approach.Genome integrity · 2017Article
- THE DECADE OF THE RABiT (2005-15).Radiation protection dosimetry · 2016Article
- Grape seed extract alleviates radiation-induced damages in human blood lymphocytes.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Developing new methods for radiation biodosimetry has been identified as a high-priority need in case of a radiological accident or nuclear terrorist attacks. A large-scale radiological incident would result in an immediate critical need to assess the radiation doses received by thousands of individuals. Casualties will be exposed to different doses and dose rates due to their geographical position and sheltering conditions, and dose rate is one of the principal factors that determine the biological consequences of a given absorbed dose. In these scenarios, high-throughput platforms are required to identify the biological dose in a large number of exposed individuals for clinical monitoring and medical treatment. The Rapid Automated Biodosimetry Tool (RABiT) is designed to be completely automated from the input of blood sample into the machine to the output of a dose estimate. The primary goal of this paper was to quantify the dose rate effects for RABiT-measured micronuclei in vitro in human lymphocytes. Blood samples from healthy volunteers were exposed in vitro to different doses of X-rays to acute and protracted doses over a period up to 24 h. The acute dose was delivered at ~1.03 Gy/min and the low dose rate exposure at ~0.31 Gy/min. The results showed that the yield of micronuclei decreases with decreasing dose rate starting at 2 Gy, whereas response was indistinguishable from that of acute exposure in the low dose region, up to 0.5 Gy. The results showed a linear-quadratic dose-response relationship for the occurrence of micronuclei for the acute exposure and a linear dose-response relationship for the low dose rate exposure.
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