ArticleOpen biology2016
C-Myc regulation by costimulatory signals modulates the generation of CD8+ memory T cells during viral infection.
Article in Open biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- eEF-2K Deficiency Boosts the Virus-Specific Effector CD8Viruses · 2024Article
- Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity.EMBO molecular medicine · 2024Article
- ER-associated degradation adapter Sel1L is required for CD8Cell reports · 2024Article
- NAC1 confines virus-specific memory formation of CD4Journal of medical virology · 2023Article
- Expression of NAC1 Restrains the Memory Formation of CD8Viruses · 2022Article
- SimiC enables the inference of complex gene regulatory dynamics across cell phenotypes.Communications biology · 2022Article
- PI3K Isoforms in CD8Current topics in microbiology and immunology · 2022Article
- Co-Regulation of Protein Coding Genes by Transcription Factor and Long Non-Coding RNA in SARS-CoV-2 Infected Cells: An In Silico Analysis.Non-coding RNA · 2021Article
- Multilevel systems biology analysis of lung transcriptomics data identifies key miRNAs and potential miRNA target genes for SARS-CoV-2 infection.Computers in biology and medicine · 2021Article
- A Role for Human Renal Tubular Epithelial Cells in Direct Allo-Recognition by CD4+ T-Cells and the Effect of Ischemia-Reperfusion.International journal of molecular sciences · 2021Article
- Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits.Nature communications · 2020Article
- Transcriptomic analysis of human IL-7 receptor alphaAging cell · 2019Article
- Stem cell-derived tissue-associated regulatory T cells suppress the activity of pathogenic cells in autoimmune diabetes.JCI insight · 2019Article
- Article
- Th1-like Plasmodium-Specific Memory CD4Cell reports · 2018Article
- Survivin Measurement improves Clinical Prediction of Transition From Arthralgia to RA-Biomarkers to Improve Clinical Sensitivity of Transition From Arthralgia to RA.Frontiers in medicine · 2018Article
- Th1-like Plasmodium-Specific Memory CD4Cell reports · 2017Article
- Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
The signalling mechanisms of costimulation in the development of memory T cells remain to be clarified. Here, we show that the transcription factor c-Myc in CD8(+) T cells is controlled by costimulatory molecules, which modulates the development of memory CD8(+) T cells. C-Myc expression was dramatically reduced in Cd28(-/-) or Ox40(-/-) memory CD8(+) T cells, and c-Myc over-expression substantially reversed the defects in the development of T-cell memory following viral infection. C-Myc regulated the expression of survivin, an inhibitor of apoptosis, which promoted the generation of virus-specific memory CD8(+) T cells. Moreover, over-expression of survivin with bcl-xL, a downstream molecule of NF-κB and intracellular target of costimulation that controls survival, in Cd28(-/-) or Ox40(-/-) CD8(+) T cells, reversed the defects in the generation of memory T cells in response to viral infection. These results identify c-Myc as a key controller of memory CD8(+) T cells from costimulatory signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.