Evidence map›Paper›PMID 26791187›Full record

Trial reportThe American journal of clinical nutrition2016

Weight-loss diets and 2-y changes in circulating amino acids in 2 randomized intervention trials.

Yan Zheng, Uta Ceglarek, Tao Huang, Lerong Li, Jennifer Rood, Donna H Ryan, George A Bray, Frank M Sacks, Dan Schwarzfuchs, Joachim Thiery and 2 more

2 registry-linked trialsOpen access · bronzeAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of clinical nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00072995 nacompletednot on this map

Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)

TypeinterventionalSponsorBrigham and Women's HospitalRan2003 to 2007Enrolled811ConditionsCardiovascular Diseases, Heart Diseases, ObesityArmsFour Diets Differing in Macronutrient Composition, Diets Low in Saturated Fat
NCT00160108 phase1completednot on this map

A Dietary Intervention- Randomized Controlled Trial (DIRECT) Study; BGU-Harvard-Robarts Collaboration

TypeinterventionalSponsorThe S. Daniel Abraham International Center for Health and NutritionRan2005 to 2007Enrolled300ConditionsObesity, CHDArmsdietary intervention
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Effects of total fat intake on body fatness in adults.The Cochrane database of systematic reviews · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Yan ZhengDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Uta CeglarekInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany;
Tao HuangDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Lerong LiHuman Genetics Center, University of Texas Health Science Center School of Public Health, Houston, TX;
Jennifer RoodPennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA;
Donna H RyanPennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA;
George A BrayPennington Biomedical Research Center of the Louisiana State University System, Baton Rouge, LA;
Frank M SacksDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA;
Dan SchwarzfuchsNuclear Research Center Negev, Dimona, Israel;
Joachim ThieryInstitute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany;
Iris ShaiDepartment of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel; and.
Lu QiDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA lqi1@tulane.edu.
Harvard University · USPennington Biomedical Research Center · USBen-Gurion University of the Negev · ILUniversity Hospital Leipzig · DEThe University of Texas Health Science Center at Houston · USTulane University · US

Funding

Dietary Macronutrients and Weight LossU01HL073286 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI SACKS, FRANK M · 2003 to 2008
$7.6M
NHLBI NIH HHS HL073286
6 · The paper itself

Abstract

backgroundCirculating amino acids, such as branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs), have been associated with diabetes risk; however, little is known about how a long-term dietary intervention for weight loss affects circulating amino acids.

objectivesWe examined the effects of weight-loss diets on long-term changes in plasma amino acids and the associations of these changes with weight loss and the improvement of insulin resistance.

designWe repeatedly measured plasma amino acid profiles over 2 y in overweight or obese participants from 2 randomized, dietary intervention, weight-loss trials [774 subjects from the POUNDS LOST (Preventing Overweight Using Novel Dietary Strategies Trial) and 318 subjects from the DIRECT (Dietary Intervention Randomized Controlled Trial)].

resultsIntervention diets consistently lowered most of the amino acid concentrations, including BCAAs and AAAs, in both trials. In the POUNDS LOST, average-protein diets (15% of daily energy) showed stronger effects than did high-protein diets (25% of daily energy) on reducing concentrations of the diabetes-associated BCAA valine at 6 mo independent of the weight change. In both trials, weight loss was directly related to the concurrent reduction of the BCAAs leucine and isoleucine, the AAAs tyrosine and phenylalanine, and 4 other amino acids. For example, per kilogram of weight loss, there was a 0.04-SD decrease in log tyrosine (∼0.6 μmol/L) in both trials. In addition, we showed that reductions in alanine and the AAA tyrosine were significantly related to improved insulin resistance (measured with the use of the homeostasis model assessment of insulin resistance), independent of weight loss, in both trials (both P < 0.05). For example, per 1-SD decrease in log tyrosine (∼17 μmol/L), there was a 0.04-SD (∼3%) improvement in insulin resistance in the POUNDS LOST and a 0.13-SD (∼8%) improvement in insulin resistance in the DIRECT.

conclusionOur findings underscore the potential importance of dietary interventions in improving amino acid profiles (i.e., reducing diabetes risk-enhancing amino acid concentrations) along with and beyond weight loss. The POUNDS LOST and the DIRECT were registered at clinicaltrials.gov as NCT00072995 and NCT00160108, respectively.

Indexed as

Diet, Fat-RestrictedDiet, ReducingInsulin ResistanceAdultAmino AcidsAmino Acids, AromaticAmino Acids, Branched-ChainBody Mass IndexBostonDiabetes Mellitus, Type 2Dietary ProteinsDown-RegulationFemaleHumansLouisianaMaleAmino AcidsAmino Acids, AromaticAmino Acids, Branched-ChainDietary Proteinsdietary interventioninsulin resistancemetabolomicsplasma amino acidsweight loss

Identifiers

PMID26791187
PMCPMC4733257
OpenAlexW2266425104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.