ArticleIntensive care medicine experimental2016
A technique for continuous bedside monitoring of global cerebral energy state.
Article in Intensive care medicine experimental, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- A randomized, double-blind trial comparing the effect of two blood pressure targets on global brain metabolism after out-of-hospital cardiac arrest.Critical care (London, England) · 2023Trial
- Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest.Scientific reports · 2021Trial
- Resuscitative endovascular occlusion of the aorta restores cerebral metabolic markers of ischaemia induced by haemorrhagic shock.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock.Intensive care medicine experimental · 2022Article
- Bedside interpretation of cerebral energy metabolism utilizing microdialysis in neurosurgical and general intensive care.Frontiers in neurology · 2022Review
- A Prospective Observational Feasibility Study of Jugular Bulb Microdialysis in Subarachnoid Hemorrhage.Neurocritical care · 2020Observational
- Moderately prolonged permissive hypotension results in reversible metabolic perturbation evaluated by intracerebral microdialysis - an experimental animal study.Intensive care medicine experimental · 2019Article
- Lactate/pyruvate monitoring during carotid endarterectomy under general anaesthesia versus cervical plexus block: A randomised controlled study.Indian journal of anaesthesia · 2017Article
- Microdialysis Monitoring in Clinical Traumatic Brain Injury and Its Role in Neuroprotective Drug Development.The AAPS journal · 2017Review
- Aspects on the Physiological and Biochemical Foundations of Neurocritical Care.Frontiers in neurology · 2017Review
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Authors and funding
5 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCerebral cytoplasmatic redox state is a sensitive indicator of cerebral oxidative metabolism and is conventionally evaluated from the extracellular lactate/pyruvate (LP) ratio. In the present experimental study of global cerebral ischemia induced by hemorrhagic shock, we investigate whether the LP ratio obtained from microdialysis of cerebral venous blood may be used as a surrogate marker of global cerebral energy state.
methodsSix female pigs were anesthetized and vital parameters were recorded. Microdialysis catheters were placed in the left parietal lobe, the superior sagittal sinus, and the femoral artery. Hemorrhagic shock was achieved by bleeding the animals to a mean arterial pressure (MAP) of approximately 40 mmHg and kept at a MAP of about 30-40 mmHg for 90 min. The animals were resuscitated with autologous whole blood followed by 3 h of observation.
resultsThe LP ratio obtained from the intracerebral and intravenous catheters immediately increased during the period of hemorrhagic shock while the LP ratio in the arterial blood remained close to normal levels. At the end of the experiment, median LP ratio (interquartile range) obtained from the intracerebral, intravenous, and intra-arterial microdialysis catheters were 846 (243-1990), 309 (103-488), and 27 (21-31), respectively. There was a significant difference in the LP ratio obtained from the intravenous location and the intra-arterial location (P < 0.001).
conclusionsDuring cerebral ischemia induced by severe hemorrhagic shock, intravascular microdialysis of the draining venous blood will exhibit changes of the LP ratio revealing the deterioration of global cerebral oxidative energy metabolism. In neurocritical care, this technique might be used to give information regarding global cerebral energy metabolism in addition to the regional information obtained from intracerebral microdialysis catheters. The technique might also be used to evaluate cerebral energy state in various critical care conditions when insertion of an intracerebral microdialysis catheter may be contraindicated, e.g., resuscitation after cardiac standstill, open-heart surgery, and multi-trauma.
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