ArticleJournal of the Royal Society, Interface2016
Hydroxyapatite formation on graphene oxide modified with amino acids: arginine versus glutamic acid.
Article in Journal of the Royal Society, Interface, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 53 citations in OpenAlex.
- Graphene oxide-modified PEEK composites: Properties and applications in orthopaedic repair - A review.Journal of orthopaedic translation · 2026Review
- Efficacy of3 Biotech · 2025Article
- External Mechanical Stability Regulates Hematoma Vascularization in Bone Healing Rather than Endothelial YAP/TAZ Mechanotransduction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering.Biopolymers · 2023Review
- Fabrication of graphene-based porous materials: traditional and emerging approaches.Chemical science · 2022Review
- Hydroxyapatite-decorated Fmoc-hydrogel as a bone-mimicking substrate for osteoclast differentiation and culture.Acta biomaterialia · 2022Article
- In Vitro Mineralization of Collagen.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Applications of Graphene and Its Derivatives in Bone Repair: Advantages for Promoting Bone Formation and Providing Real-Time Detection, Challenges and Future Prospects.International journal of nanomedicine · 2020Review
- Contribution of TRPC Channels in Neuronal Excitotoxicity Associated With Neurodegenerative Disease and Ischemic Stroke.Frontiers in cell and developmental biology · 2020Article
- Hema-Functionalized Graphene Oxide: a Versatile Nanofiller for Poly(Propylene Fumarate)-Based Hybrid Materials.Scientific reports · 2019Article
- Biomimetic Hydroxyapatite on Graphene Supports for Biomedical Applications: A Review.Nanomaterials (Basel, Switzerland) · 2019Review
- Accelerated mineralization on nanofibers via non-thermal atmospheric plasma assisted glutamic acid templated peptide conjugation.Regenerative biomaterials · 2019Article
- An overview of graphene-based hydroxyapatite composites for orthopedic applications.Bioactive materials · 2018Review
- The role of amino acids in hydroxyapatite mineralization.Journal of the Royal Society, Interface · 2016Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydroxyapatite (HA, Ca5(PO4)3OH) is the main inorganic component of hard tissues, such as bone and dentine. HA nucleation involves a set of negatively charged phosphorylated proteins known as non-collagenous proteins (NCPs). These proteins attract Ca(2+) and PO4(3-) ions and increase the local supersaturation to a level required for HA precipitation. Polar and charged amino acids (AAs) are highly expressed in NCPs, and seem to be responsible for the mineralizing effect of NCPs; however, the individual effect of these AAs on HA mineralization is still unclear. In this work, we investigate the effect of a negatively charged (Glu) and positively charged (Arg) AA bound to carboxylated graphene oxide (CGO) on HA mineralization in simulated body fluids (SBF). Our results show that Arg induces HA precipitation faster and in larger amounts than Glu. We attribute this to the higher stability of the complexes formed between Arg and Ca(2+) and PO4(3-) ions, and also to the fact that Arg exposes both carboxyl and amino groups on the surface. These can electrostatically attract both Ca(2+) and PO4(3-) ions, thus increasing local supersaturation more than Glu, which exposes carboxyl groups only.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.