Evidence map›Paper›PMID 26790968›Full record

ArticleCancer research and treatment2016

Polymorphic Variants in Oxidative Stress Genes and Acute Toxicity in Breast Cancer Patients Receiving Radiotherapy.

Elisa Eugenia Córdoba, Martín Carlos Abba, Ezequiel Lacunza, Eduardo Fernánde, Alba Mabel Güerci

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer research and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Elisa Eugenia CórdobaDepartment of Physics, School of Exact Sciences, National University of La Plata, Argentina.
Martín Carlos AbbaBasic and Applied Immunological Research Center, School of Medicine, National University of La Plata, Argentina.
Ezequiel LacunzaBasic and Applied Immunological Research Center, School of Medicine, National University of La Plata, Argentina.
Eduardo Fernánde21st Century Oncology, Naples, FL, USA.
Alba Mabel GüerciDepartment of Physics, School of Exact Sciences, National University of La Plata, Argentina.
Universidad Nacional de La Plata · AR21st Century Oncology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeReactive oxygen species (ROS) are generated as an indirect product of radiation therapy (RT). Genetic variation in genes related to ROS metabolism may influence the level of RT-induced adverse effects. We evaluated the potential association of single nucleotide polymorphism (SNP)-related response to radiotherapy injury in breast cancer patients undergoing RT. MATERIALS AND

methodsEighty patients receiving conventional RT were included. Acute effects were evaluated according to the Radiation Therapy Oncology Group (RTOG) scores. DNA was extracted from blood and buccal swab samples. SNPs were genotyped for GSTP1, GSTA1, SOD2, and NOS3 genes by polymerase chain reaction-based restriction fragment length polymorphism. Univariate analysis (odds ratios [ORs] and 95% confidence interval [CI]) and principal component analysis were used for correlation of SNPs and factors related to risk of developing ≥ grade 2 acute effects.

resultsSixty-five patients (81.2%) showed side effects, 32 (40%) presented moderate to severe acute skin toxicity, and 33 (41.2%) manifested minimal acute skin reactions by the end of treatment. In both univariate and multivariate analyses, nominally significant associations were found among body mass index (OR, 3.14; 95% CI, 8.5338 to 1.1274; p=0.022), breast size (OR, 5.11; 95% CI, 17.04 to 1.54; p=0.004), and grade ≥ 2 acute radiation skin toxicity. A significant association was also observed between NOS3 G894T polymorphism (OR, 9.8; 95% CI, 211.6 to 0.45; p=0.041) and grade ≥ 2 acute radiation skin toxicity in patients with neo-adjuvant chemotherapy treatment.

conclusionThe analysis of the factors involved in individual radiosensitivity contributed to the understanding of the mechanisms underlying this trait.

Indexed as

AdultAgedAge FactorsAmplified Fragment Length Polymorphism AnalysisBreast NeoplasmsFemaleGenotypeGenotyping TechniquesGlutathione S-Transferase piGlutathione TransferaseHumansMiddle AgedNeoadjuvant TherapyNitric Oxide Synthase Type IIIOdds RatioOxidative StressGlutathione S-Transferase piGlutathione TransferaseGSTA1 protein, humanGSTP1 protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanReactive Oxygen SpeciesSuperoxide DismutaseSuperoxide Dismutase 2Acute toxicityBreast neoplasmOxidative stressRadiation toleranceRadiotherapySingle nucleotide polymorphism

Identifiers

PMID26790968
PMCPMC4946367
OpenAlexW2238015889

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.