ReviewAnnals of biomedical engineering2016
Application of Elastography for the Noninvasive Assessment of Biomechanics in Engineered Biomaterials and Tissues.
Review in Annals of biomedical engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Evaluation of Engineered Cartilage Composition and Function Using Raman Spectroscopy.Advanced healthcare materials · 2025Article
- MRI-derived articular cartilage strains predict patient-reported outcomes six months post anterior cruciate ligament reconstruction.Scientific reports · 2025Article
- Article
- Nondestructive Mechanical Characterization of Bioengineered Tissues by Digital Holography.ACS biomaterials science & engineering · 2025Article
- Integrative cartilage repair using acellular allografts for engineered structure and surface lubrication in vivo.NPJ Regenerative medicine · 2024Article
- Spatial Gradients of Quantitative MRI as Biomarkers for Early Detection of Osteoarthritis: Data From Human Explants and the Osteoarthritis Initiative.Journal of magnetic resonance imaging : JMRI · 2023Article
- Fibrin and Marine-Derived Agaroses for the Generation of Human Bioartificial Tissues: An Ex Vivo and In Vivo Study.Marine drugs · 2023Article
- High frame rate deformation analysis of knee cartilage by spiral dualMRI and relaxation mapping.Magnetic resonance in medicine · 2023Article
- Nondestructive testing of native and tissue-engineered medical products: adding numbers to pictures.Trends in biotechnology · 2022Review
- Effects of Loading and Boundary Conditions on the Performance of Ultrasound Compressional Viscoelastography: A Computational Simulation Study to Guide Experimental Design.Materials (Basel, Switzerland) · 2021Article
- Image-Based Elastography of Heterochromatin and Euchromatin Domains in the Deforming Cell Nucleus.Small (Weinheim an der Bergstrasse, Germany) · 2021Article
- Medical imaging of tissue engineering and regenerative medicine constructs.Biomaterials science · 2021Review
- In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion-extension.Scientific reports · 2021Article
- Computational models of melanoma.Theoretical biology & medical modelling · 2020Review
- Finite deformation elastography of articular cartilage and biomaterials based on imaging and topology optimization.Scientific reports · 2020Article
- Spatial localization of mechanical excitation affects spatial resolution, contrast, and contrast-to-noise ratio in acoustic radiation force optical coherence elastography.Biomedical optics express · 2019Article
- Functional MRI can detect changes in intratissue strains in a full thickness and critical sized ovine cartilage defect model.Journal of biomechanics · 2018Article
- Alzheimer's Disease Mutant Mice Exhibit Reduced Brain Tissue Stiffness Compared to Wild-type Mice in both Normoxia and following Intermittent Hypoxia Mimicking Sleep Apnea.Frontiers in neurology · 2018Article
- Indentation mapping revealed poroelastic, but not viscoelastic, properties spanning native zonal articular cartilage.Acta biomaterialia · 2017Article
- Predicting in vivo behavior of injectable, in situ-forming drug-delivery systems.Therapeutic delivery · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The elastic properties of engineered biomaterials and tissues impact their post-implantation repair potential and structural integrity, and are critical to help regulate cell fate and gene expression. The measurement of properties (e.g., stiffness or shear modulus) can be attained using elastography, which exploits noninvasive imaging modalities to provide functional information of a material indicative of the regeneration state. In this review, we outline the current leading elastography methodologies available to characterize the properties of biomaterials and tissues suitable for repair and mechanobiology research. We describe methods utilizing magnetic resonance, ultrasound, and optical coherent elastography, highlighting their potential for longitudinal monitoring of implanted materials in vivo, in addition to spatiotemporal limits of each method for probing changes in cell-laden constructs. Micro-elastography methods now allow acquisitions at length scales approaching 5-100 μm in two and three dimensions. Many of the methods introduced in this review are therefore capable of longitudinal monitoring in biomaterials and tissues approaching the cellular scale. However, critical factors such as anisotropy, heterogeneity and viscoelasity-inherent in many soft tissues-are often not fully described and therefore require further advancements and future developments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.