Evidence map›Paper›PMID 26790773›Full record

ArticleGynecologic oncology2016

The impact of FDG-PET/CT in the management of patients with vulvar and vaginal cancer.

N L Robertson, H Hricak, Y Sonoda, R E Sosa, M Benz, G Lyons, N R Abu-Rustum, E Sala, H A Vargas

Abstract read
In one paragraph

Article in Gynecologic oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Cancer of the vulva: 2025 update: FIGO Cancer Report 2025.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025
    Article
  3. Article
  4. Review
  5. The potential advantages ofQuantitative imaging in medicine and surgery · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Clinical and prognosticJapanese journal of radiology · 2022
    Article
  10. Review
  11. Current update on vaginal malignancies.Abdominal radiology (New York) · 2021
    Review
  12. Cancer of the vulva: 2021 update.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2021
    Article
  13. Diagnostic performance of preoperative [European journal of nuclear medicine and molecular imaging · 2021
    Article
  14. Personalizing vulvar cancer workflow in COVID-19 era: a proposal from Vul.Can MDT.Journal of cancer research and clinical oncology · 2020
    Article
  15. When an Unexpected Diagnosis Occurs: a Vaginal Premenopausal Sarcoma.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2018
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

N L RobertsonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA. Electronic address: Robertn1@mskcc.org.
H HricakDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
Y SonodaGynecologic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
R E SosaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
M BenzDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
G LyonsDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
N R Abu-RustumGynecologic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
E SalaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
H A VargasDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Av, room C278, New York, NY 10065, USA.
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Elisa de Stanchina · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectivesTo evaluate the changes in prognostic impression and patient management following PET/CT in patients with vulvar and vaginal carcinoma; and to compare PET/CT findings with those of conventional imaging modalities.

methodsWe summarized prospectively and retrospectively collected data for 50 consecutive patients from our institution that enrolled in the National Oncologic PET Registry and underwent FDG-PET/CT for a suspected or known primary or recurrent vulvar/vaginal cancer.

results54/83 (65%) studies included had a diagnosis of vulvar cancer, and the remaining 29/83 (35%), a diagnosis of vaginal cancer. Following FDG-PET/CT, the physician's prognostic impression changed in 51% of cases. A change in patient management, defined as a change to/from a non-interventional strategy (observation or additional imaging), to/from an interventional strategy (biopsy or treatment), was documented in 36% of studies. The electronic records demonstrated that 95% of the management strategies recorded in the physician questionnaires were implemented as planned. MRI and/or CT were performed within one month of the FDG-PET/CT in 20/83 (24%) and 28/83 (34%) cases, respectively. FDG-PET/CT detected nodes suspicious for metastases on 29/83 (35%) studies performed. MRI and CT detected positive nodes on 6 and 11 studies respectively. Distant metastases were identified in 10 cases imaged with FDG-PET and 5 cases that had additional conventional CT imaging. All suspicious lesions seen on CT were positively identified on PET/CT. In 4 cases, an abnormality identified on PET/CT, was not seen on diagnostic CT.

conclusionsFDG-PET/CT may play an important role in the management of vulvar and vaginal carcinoma.

Indexed as

Positron-Emission TomographyTomography, X-Ray ComputedCarcinomaDisease ManagementFemaleFluorodeoxyglucose F18HumansLymphatic MetastasisMultimodal ImagingPrognosisProspective StudiesRadiopharmaceuticalsRetrospective StudiesVaginal NeoplasmsVulvar NeoplasmsFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID26790773
PMCPMC4988238
OpenAlexW2234712294

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.