ArticleBrain, behavior, and immunity2016
Glucocorticoids enhance the in vivo migratory response of human monocytes.
Article in Brain, behavior, and immunity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia.Diabetologia · 2026Trial
- Inflammatory marker dynamics in shift work sleep disorder: a data-driven approach among rotating shift workers.Frontiers in neuroscience · 2026Article
- Endogenous glucocorticoids and human immunity: Time to revisit old dogmas.Seminars in immunology · 2025Review
- Preconditioning donors with corticosteroids improves early lung graft immunity.Frontiers in immunology · 2025Article
- Glucocorticoid boluses followed by tocilizumab in giant cell arteritis patients: effects on peripheral blood monocytes and lymphocytes.Frontiers in immunology · 2025Article
- Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis.ERJ open research · 2024Article
- Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2 Diabetes Subjects.International journal of molecular sciences · 2022Article
- Cause or consequence? Understanding the role of cortisol in the increased inflammation observed in depression.Current opinion in endocrine and metabolic research · 2022Article
- Monocyte Count as a Prognostic Biomarker in Patients with Idiopathic Pulmonary Fibrosis.American journal of respiratory and critical care medicine · 2021Article
- Cold Water Swimming-Benefits and Risks: A Narrative Review.International journal of environmental research and public health · 2020Review
- Unique maternal immune and functional microbial profiles during prenatal stress.Scientific reports · 2020Article
- Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids.Current biology : CB · 2019Article
- Randomized field trial on the effects of body weight and short transport on stress and immune variables in 2- to 4-week-old dairy calves.Journal of veterinary internal medicine · 2019Article
- Neuroendocrine Control of Macrophage Development and Function.Frontiers in immunology · 2018Review
- Effect of β-agonist on the dexamethasone-induced expression of aromatase by the human monocyte cells.Endocrine connections · 2017Article
- Status of M1 and M2 type macrophages in keloid.International journal of clinical and experimental pathology · 2017Article
- Memory Training Program Decreases the Circulating Level of Cortisol and Pro-inflammatory Cytokines in Healthy Older Adults.Frontiers in molecular neuroscience · 2017Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Glucocorticoids (GCs) are best known for their potent anti-inflammatory effects. However, an emerging model for glucocorticoid (GC) regulation of in vivo inflammation also includes a delayed, preparatory effect that manifests as enhanced inflammation following exposure to an inflammatory stimulus. When GCs are transiently elevated in vivo following exposure to a stressful event, this model proposes that a subsequent period of increased inflammatory responsiveness is adaptive because it enhances resistance to a subsequent stressor. In the present study, we examined the migratory response of human monocytes/macrophages following transient in vivo exposure to stress-associated concentrations of cortisol. Participants were administered cortisol for 6h to elevate in vivo cortisol levels to approximate those observed during major systemic stress. Monocytes in peripheral blood and macrophages in sterile inflammatory tissue (skin blisters) were studied before and after exposure to cortisol or placebo. We found that exposure to cortisol induced transient upregulation of monocyte mRNA for CCR2, the receptor for monocyte chemotactic protein-1 (MCP-1/CCL2) as well as for the chemokine receptor CX3CR1. At the same time, mRNA for the transcription factor IκBα was decreased. Monocyte surface expression of CCR2 but not CX3CR1 increased in the first 24h after cortisol exposure. Transient exposure to cortisol also led to an increased number of macrophages and neutrophils in fluid derived from a sterile inflammatory site in vivo. These findings suggest that the delayed, pro-inflammatory effects of cortisol on the human inflammatory responses may include enhanced localization of effector cells at sites of in vivo inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.