ArticleCardiovascular diabetology2016
The ratio of skeletal muscle mass to visceral fat area is a main determinant linking circulating irisin to metabolic phenotype.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial.Journal of diabetes research · 2024Trial
- Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population.Journal of neuroinflammation · 2018Trial
- Mesenteric Visceral Lipectomy Improves Glucose Tolerance in Patients With Type 2 Diabetes: A Pilot Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Clinical application of cluster analysis in patients with newly diagnosed type 2 diabetes.Hormones (Athens, Greece) · 2025Article
- Concentrations of Glypican-4, Irisin and Total Antioxidant Status in Women with Metabolic Syndrome: Influence of Physical Activity.Biomolecules · 2024Article
- Association of Plasma Irisin Levels with Circulating Endothelial Microparticles (EMPs) and Endothelial Progenitor Cells (EPCs) in Children Born Prematurely.Metabolites · 2023Article
- Anticipated correlation between lean body mass to visceral fat mass ratio and insulin resistance: NHANES 2011-2018.Frontiers in endocrinology · 2023Article
- The Effect of Exercise Training on Irisin Secretion in Patients with Type 2 Diabetes: A Systematic Review.Journal of clinical medicine · 2022Review
- Non-linear Associations Between Visceral Adipose Tissue Distribution and Anthropometry-Based Estimates of Visceral Adiposity.Frontiers in nutrition · 2022Article
- The opposing trends of body mass index and blood pressure during 1977-2020; nationwide registry of 2.8 million male and female adolescents.Cardiovascular diabetology · 2021Article
- Irisin plays an important role in the outcomes of newly diagnosed prediabetes in adults in Guiyang, China.Journal of diabetes investigation · 2021Article
- Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Circulating Irisin in Healthy Adults: Changes after Acute Exercise, Correlation with Body Composition, and Energy Expenditure Parameters in Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2020Article
- Exercise-Induced Circulating Irisin Level Is Correlated with Improved Cardiac Function in Rats.International journal of environmental research and public health · 2020Article
- Effect of Long-Term Moderate Physical Exercise on Irisin between Normal Weight and Obese Men.TheScientificWorldJournal · 2020Article
- Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome.Journal of diabetes research · 2020Article
- Relationships Between Circulating Irisin Response to Ice Swimming and Body Composition in People With Regular Exercise Experience.Frontiers in physiology · 2020Article
- Low muscle quality in Japanese type 2 diabetic patients with visceral fat accumulation.Cardiovascular diabetology · 2018Article
- Does iris(in) bring bad news or good news?Eating and weight disorders : EWD · 2018Review
- Observational
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aims of this study were to investigate whether circulating irisin is associated with favorable metabolic parameters and how the association differs according to body composition in humans.
methodsA total of 424 subjects (233 men and 191 women), aged 23-73 years (mean age 47.1 years), were enrolled from the Seoul Metro City Diabetes Prevention Program. Body composition was determined using an impedance body composition analyzer, and serum irisin level was measured using a commercial kit.
resultsSerum irisin was correlated with favorable metabolic parameters including less obese, lower blood pressure and glucose levels and healthy lipid parameters. The skeletal muscle mass to visceral fat area ratio (SVR) was positively correlated with the serum irisin concentration (r = 0.10, P = 0.04). When the study subjects were divided into tertiles according to their SVR, serum irisin was correlated with favorable metabolic phenotypes in those subjects in the upper tertile. However, there were no such correlations in the lower tertile. In addition, serum irisin was inversely related to pre-diabetes/type 2 diabetes (T2D) independent of other risk factor for T2D and insulin resistance [OR (95 % CI); 0.66 (0.49-0.90), P = 0.009].
conclusionsThe compositions of skeletal muscle and visceral fat play key roles in the association between circulating irisin and a patient's metabolic phenotype.
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