ArticleBiomaterials2016
Surface modification of a POSS-nanocomposite material to enhance cellular integration of a synthetic bioscaffold.
Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed.
- Liquid Trisilanol i-Octyl POSS Achieves Rapid Hemostasis and Pneumostasis in Experimental Lung Injury.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Most Important Biomedical and Pharmaceutical Applications of Silicones.Materials (Basel, Switzerland) · 2025Review
- Excited State Dynamics Govern Emission Properties of Unique Silsesquioxane-Salphen-Based Zinc Compounds.The journal of physical chemistry letters · 2025Article
- POSS and SSQ Materials in Dental Applications: Recent Advances and Future Outlooks.International journal of molecular sciences · 2023Review
- Advances in lung bioengineering: Where we are, where we need to go, and how to get there.Frontiers in transplantation · 2023Review
- Human epidermal keratinocytes and human dermal fibroblasts interactions seeded on gelatin hydrogel for future application in skinFrontiers in bioengineering and biotechnology · 2023Article
- A sheet pocket to prevent cross-contamination of formalin-fixed paraffin-embedded block for application in next generation sequencing.PloS one · 2022Article
- Recent Advances in Polyurethane/POSS Hybrids for Biomedical Applications.Molecules (Basel, Switzerland) · 2021Review
- Article
- ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the AirwaysFrontiers in immunology · 2021Article
- Extracellular-Matrix-Reinforced Bioinks for 3D Bioprinting Human Tissue.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Synthetic Routes to Silsesquioxane-Based Systems as Photoactive Materials and Their Precursors.Polymers · 2019Review
- Monitoring neovascularization and integration of decellularized human scaffolds using photoacoustic imaging.Photoacoustics · 2019Article
- Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel.Acta biomaterialia · 2019Article
- Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction.Materials science & engineering. C, Materials for biological applications · 2018Article
- Genome-Wide Posttranscriptional Dysregulation by MicroRNAs in Human Asthma as Revealed by Frac-seq.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Novel poss reinforced chitosan composite membranes for guided bone tissue regeneration.Journal of materials science. Materials in medicine · 2017Article
- Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds.Biomaterials · 2017Article
- Autologous Cell Seeding in Tracheal Tissue Engineering.Current stem cell reports · 2017Review
- TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy.Journal of extracellular vesicles · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) is a versatile nanocomposite biomaterial with growing applications as a bioscaffold for tissue engineering. Integration of synthetic implants with host tissue can be problematic but could be improved by topographical modifications. We describe optimization of POSS-PCU by dispersion of porogens (sodium bicarbonate (NaHCO3), sodium chloride (NaCl) and sucrose) onto the material surface, with the principle aim of increasing surface porosity, thus providing additional opportunities for improved cellular and vascular ingrowth. We assess the effect of the porogens on the material's mechanical strength, surface chemistry, wettability and cytocompatibilty. Surface porosity was characterized by scanning electron microscopy (SEM). There was no alteration in surface chemistry and wettability and only modest changes in mechanical properties were detected. The size of porogens correlated well with the porosity of the construct produced and larger porogens improved interconnectivity of spaces within constructs. Using primary human bronchial epithelial cells (HBECs) we demonstrate moderate in vitro cytocompatibility for all surface modifications; however, larger pores resulted in cellular aggregation. These cells were able to differentiate on POSS-PCU scaffolds. Implantation of the scaffold in vivo demonstrated that larger pore sizes favor cellular integration and vascular ingrowth. These experiments demonstrate that surface modification with large porogens can improve POSS-PCU nanocomposite scaffold integration and suggest the need to strike a balance between the non-porous surfaces required for epithelial coverage and the porous structure required for integration and vascularization of synthetic scaffolds in future construct design.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.