Evidence map›Paper›PMID 26790146›Full record

ArticleBiomaterials2016

Engineered protein coatings to improve the osseointegration of dental and orthopaedic implants.

Jordan Raphel, Johan Karlsson, Silvia Galli, Ann Wennerberg, Christopher Lindsay, Matthew G Haugh, Jukka Pajarinen, Stuart B Goodman, Ryo Jimbo, Martin Andersson and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 122 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Biomimetic Coatings in Implant Dentistry: A Quick Update.Journal of functional biomaterials · 2023
    Review
  9. Article
  10. Article
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  17. Review
  18. Biodegradable materials for bone defect repair.Military Medical Research · 2020
    Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jordan RaphelDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Johan KarlssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Silvia GalliDepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Ann WennerbergDepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Christopher LindsayDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Matthew G HaughDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Jukka PajarinenDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Stuart B GoodmanDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA.
Ryo JimboDepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden; Department of Oral and Maxillofacial Surgery and Oral Medicine, Faculty of Odontology, Malmö University, Malmö, Sweden.
Martin AnderssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
Sarah C HeilshornDepartment of Materials Science and Engineering, Stanford University, Stanford, CA, USA. Electronic address: heilshorn@stanford.edu.
Stanford University · USMalmö University · SEChalmers University of Technology · SE

Funding

Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI KUO, CALVIN J · 2015 to 2025
$13.5M
Wear Particle Disease and NF-kappa B SignalingR01AR063717 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2012 to 2021
$3.5M
Chemokine Directed Cell Trafficking during Continuous Infusion of Wear ParticlesR01AR055650 · NIAMS · STANFORD UNIVERSITY · PI GOODMAN, STUART B · 2007 to 2016
$3.3M
Engineered Intestinal Microenvironments as Preclinical Drug Screening PlatformsR21EB018407 · NIBIB · STANFORD UNIVERSITY · PI HEILSHORN, SARAH C · 2014 to 2015
$427k
3D Bioengineering Strategies to Mimic Human Skeletal Muscle Progenitor Cell NicheR21AR062359 · NIAMS · STANFORD UNIVERSITY · PI BLAU, HELEN M, HEILSHORN, SARAH C · 2011 to 2012
$367k
NIAID NIH HHS U19 AI116484NIAID NIH HHS U19 AI116484-01NIAMS NIH HHS 2R01 AR055650NIAMS NIH HHS R01 AR055650NIAMS NIH HHS R01 AR063717NIAMS NIH HHS R21 AR062359NIAMS NIH HHS R21 AR062359-01NIBIB NIH HHS R21 EB018407NIBIB NIH HHS R21 EB018407-01PHS HHS R01 063717
6 · The paper itself

Abstract

Here we present the design of an engineered, elastin-like protein (ELP) that is chemically modified to enable stable coatings on the surfaces of titanium-based dental and orthopaedic implants by novel photocrosslinking and solution processing steps. The ELP includes an extended RGD sequence to confer bio-signaling and an elastin-like sequence for mechanical stability. ELP thin films were fabricated on cp-Ti and Ti6Al4V surfaces using scalable spin and dip coating processes with photoactive covalent crosslinking through a carbene insertion mechanism. The coatings withstood procedures mimicking dental screw and hip replacement stem implantations, a key metric for clinical translation. They promoted rapid adhesion of MG63 osteoblast-like cells, with over 80% adhesion after 24 h, compared to 38% adhesion on uncoated Ti6Al4V. MG63 cells produced significantly more mineralization on ELP coatings compared to uncoated Ti6Al4V. Human bone marrow mesenchymal stem cells (hMSCs) had an earlier increase in alkaline phosphatase activity, indicating more rapid osteogenic differentiation and mineral deposition on adhesive ELP coatings. Rat tibia and femur in vivo studies demonstrated that cell-adhesive ELP-coated implants increased bone-implant contact area and interfacial strength after one week. These results suggest that ELP coatings withstand surgical implantation and promote rapid osseointegration, enabling earlier implant loading and potentially preventing micromotion that leads to aseptic loosening and premature implant failure.

Indexed as

Dental ImplantsOrthopedicsProtein EngineeringAnimalsBone and BonesBone Marrow CellsCalcification, PhysiologicCell AdhesionCell DifferentiationCell LineCoated Materials, BiocompatibleElastinFemaleHumansMesenchymal Stem CellsOsseointegrationCoated Materials, BiocompatibleDental ImplantsElastinTitaniumBiomedical applicationsEngineered proteinsFunctional coatingsHydrogelsTissue engineering

Identifiers

PMID26790146
PMCPMC4771523
OpenAlexW2226383423

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.