ArticlePloS one2016
Effect of Age on Survival Outcome in Operated and Non-Operated Patients with Colon Cancer: A Population-Based Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Targeted Therapy in the Palliative Setting of Colorectal Cancer-Survival and Medical Costs.Cancers · 2023Article
- Predictors of colorectal cancer survival using cox regression and random survival forests models based on gene expression data.PloS one · 2021Article
- Application of a non-parametric non-mixture cure rate model for analyzing the survival of patients with colorectal cancer in Iran.Epidemiology and health · 2018Article
- The impacts of surgery of the primary cancer and radiotherapy on the survival of patients with metastatic rectal cancer.Oncotarget · 2017Article
- Clinicopathologic features and prognostic factors for patients with colorectal cancer who are 75 years and older.Oncotarget · 2017Article
- New trend in colorectal cancer in Germany: are young patients at increased risk for advanced colorectal cancer?World journal of surgical oncology · 2017Article
- Chemotherapy Use and Survival Among Young and Middle-Aged Patients With Colon Cancer.JAMA surgery · 2017Article
- Biomarkers for Stratification in Colorectal Cancer: MicroRNAs.Cancer control : journal of the Moffitt Cancer CenterReview
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Authors and funding
4 authors.
Funding
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Abstract
objectiveTo know the effect of age on survival outcome in operated and non-operated patients with colon cancer.
methodsFrom the Surveillance, Epidemiology, and End Results database, we identified 123,356 patients with colon cancer who were diagnosed between 1996 and 2005, grouped them as older or younger than 40 years and analyzed their 5-year cancer-specific survival (CSS) data, along with some risk factors, using Kaplan-Meier methods and multivariable Cox regression models.
resultsThe younger group had significantly higher pathological grades (P<0.001), more mucinous and signet-ring histology (P<0.001), advanced AJCC stage (P<0.001), and were more likely to undergo surgery (P<0.001). For surgically treated patients, age did not significantly affect 5-year CSS (younger: 66.7%; older: 67.3%; P = 0.86). Further analysis showed that age was an independent prognostic factor in stage I-IV disease (stage I: P = 0.001; P<0.001 for stages II-IV, in both uni- and multivariate analyses), but not for patients with unknown disease stage (P = 0.52). For non-surgically treated patients, age significantly affected 5-year CSS (younger: 16.2%; older: 12.9%; P<0.001) in univariate analysis; and was an independent prognostic factor (P<0.001) in multivariate analysis.
conclusionThe CSS rate for younger CC patients was at least as high as for older patients, although they presented with higher proportions of unfavorable factors and more advanced disease.
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