ArticleBiophysical journal2016
The Role of Stress Fibers in the Shape Determination Mechanism of Fish Keratocytes.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed, 18 citations in OpenAlex.
- Stress fiber contraction induces cell body rotation in single keratocytes.Biophysics and physicobiology · 2025Article
- A low-cost electric micromanipulator and its application to single-cell electroporation.Biophysics and physicobiology · 2025Article
- Leading-edge elongation by follower cell interruption in advancing epithelial cell sheets.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networks.PLoS genetics · 2020Article
- Rotation of stress fibers as a single wheel in migrating fish keratocytes.Scientific reports · 2018Article
- Kinetic stability analysis of protein assembly on the center manifold around the critical point.BMC systems biology · 2017Article
- Hybrid mechanosensing system to generate the polarity needed for migration in fish keratocytes.Cell adhesion & migration · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Crawling cells have characteristic shapes that are a function of their cell types. How their different shapes are determined is an interesting question. Fish epithelial keratocytes are an ideal material for investigating cell shape determination, because they maintain a nearly constant fan shape during their crawling locomotion. We compared the shape and related molecular mechanisms in keratocytes from different fish species to elucidate the key mechanisms that determine cell shape. Wide keratocytes from cichlids applied large traction forces at the rear due to large focal adhesions, and showed a spatially loose gradient associated with actin retrograde flow rate, whereas round keratocytes from black tetra applied low traction forces at the rear small focal adhesions and showed a spatially steep gradient of actin retrograde flow rate. Laser ablation of stress fibers (contractile fibers connected to rear focal adhesions) in wide keratocytes from cichlids increased the actin retrograde flow rate and led to slowed leading-edge extension near the ablated region. Thus, stress fibers might play an important role in the mechanism of maintaining cell shape by regulating the actin retrograde flow rate.
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Registered trials
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