Trial reportPloS one2016
Surface-Based Analyses of Anatomical Properties of the Visual Cortex in Macular Degeneration.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Video-evoked neuromarkers of visual function in age-related macular degeneration.Frontiers in human neuroscience · 2025Article
- Cortical plasticity in central vision loss: Cortical thickness and neurite structure.Human brain mapping · 2023Article
- Assessing the structure of the posterior visual pathway in bilateral macular degeneration.Scientific reports · 2023Article
- Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study.Alzheimer's research & therapy · 2022Article
- Cortical Atrophy Predicts Visual Performance in Long-Term Central Retinal Disease; GCL, pRNFL and Cortical Thickness Are Key Biomarkers.Investigative ophthalmology & visual science · 2022Article
- Advantages of Using Both Voxel- and Surface-based Morphometry in Cortical Morphology Analysis: A Review of Various Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Review
- Functional Connectivity Hypointensity of Middle Cingulate Gyrus and Thalamus in Age-Related Macular Degeneration Patients: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in aging neuroscience · 2022Article
- Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake.Frontiers in psychiatry · 2022Article
- Cortical Morphological Changes in Congenital Amusia: Surface-Based Analyses.Frontiers in psychiatry · 2021Article
- Cortical Thickness Related to Compensatory Viewing Strategies in Patients With Macular Degeneration.Frontiers in neuroscience · 2021Article
- Cerebral Modifications and Visual Pathway Reorganization in Maculopathy: A Systematic Review.Frontiers in neuroscience · 2020Review
- Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging.Translational vision science & technology · 2019Article
- Adaptation of visual cortex to damage of visual pathways in suprasellar tumors before and after gamma knife radiosurgery.Journal of neuro-oncology · 2019Article
- Diffusivity and quantitative T1 profile of human visual white matter tracts after retinal ganglion cell damage.NeuroImage. Clinical · 2019Article
- Visual brain plasticity induced by central and peripheral visual field loss.Brain structure & function · 2018Article
- Environmental Enrichment and Successful Aging.Frontiers in behavioral neuroscience · 2018Review
- Effects of acute peripheral/central visual field loss on standing balance.Experimental brain research · 2017Article
- Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss.Scientific reports · 2017Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Visual Cortex Plasticity Following Peripheral Damage To The Visual System: fMRI Evidence.Current neurology and neuroscience reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
introductionMacular degeneration (MD) can cause a central visual field defect. In a previous study, we found volumetric reductions along the entire visual pathways of MD patients, possibly indicating degeneration of inactive neuronal tissue. This may have important implications. In particular, new therapeutic strategies to restore retinal function rely on intact visual pathways and cortex to reestablish visual function. Here we reanalyze the data of our previous study using surface-based morphometry (SBM) rather than voxel-based morphometry (VBM). This can help determine the robustness of the findings and will lead to a better understanding of the nature of neuroanatomical changes associated with MD.
methodsThe metrics of interest were acquired by performing SBM analysis on T1-weighted MRI data acquired from 113 subjects: patients with juvenile MD (JMD; n = 34), patients with age-related MD (AMD; n = 24) and healthy age-matched controls (HC; n = 55).
resultsRelative to age-matched controls, JMD patients showed a thinner cortex, a smaller cortical surface area and a lower grey matter volume in V1 and V2, while AMD patients showed thinning of the cortex in V2. Neither patient group showed a significant difference in mean curvature of the visual cortex. DISCUSSION: The thinner cortex, smaller surface area and lower grey matter volume in the visual cortex of JMD patients are consistent with our previous results showing a volumetric reduction in their visual cortex. Finding comparable results using two rather different analysis techniques suggests the presence of marked cortical degeneration in the JMD patients. In the AMD patients, we found a thinner cortex in V2 but not in V1. In contrast to our previous VBM analysis, SBM revealed no volumetric reductions of the visual cortex. This suggests that the cortical changes in AMD patients are relatively subtle, as they apparently can be missed by one of the methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.