Evidence map›Paper›PMID 26788909›Full record

ReviewOncotarget2016

Autophagy-associated immune responses and cancer immunotherapy.

Hongming Pan, Liuxi Chen, Yinghua Xu, Weidong Han, Fang Lou, Weiqiang Fei, Shuiping Liu, Zhao Jing, Xinbing Sui

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 91 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Hongming PanDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Liuxi ChenDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Yinghua XuDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Weidong HanDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Fang LouDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Weiqiang FeiBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Shuiping LiuBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Zhao JingBiomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, China.
Xinbing SuiDepartment of Medical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.
Blood Center of Zhejiang Province · CNSir Run Run Shaw Hospital · CNZhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is an evolutionarily conserved catabolic process by which cellular components are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal degradation and recycling. Accumulating evidence suggests that autophagy plays a critical role in cell survival, senescence and homeostasis, and its dysregulation is associated with a variety of diseases including cancer, cardiovascular disease, neurodegeneration. Recent studies show that autophagy is also an important regulator of cell immune response. However, the mechanism by which autophagy regulates tumor immune responses remains elusive. In this review, we will describe the role of autophagy in immune regulation and summarize the possible molecular mechanisms that are currently well documented in the ability of autophagy to control cell immune response. In addition, the scientific and clinical hurdles regarding the potential role of autophagy in cancer immunotherapy will be discussed.

Indexed as

ImmunotherapyAnimalsAutophagyHumansMetabolic Networks and PathwaysNeoplasmsautophagycancer immunotherapyimmune

Identifiers

PMID26788909
PMCPMC5008281
OpenAlexW2291350642

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.