ArticleJournal of neurotrauma2016
A Unilateral Cervical Spinal Cord Contusion Injury Model in Non-Human Primates (Macaca mulatta).
Article in Journal of neurotrauma, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Extensive restoration of forelimb function in primates with spinal cord injury by neural stem cell transplantation.Nature biotechnology · 2026Article
- Article
- Spinal Cord Injury in Real Time: Intra-Operative Ultrasound for Acute Phase Examination in Non-Human Primates.Brain sciences · 2025Article
- Animal Models of Spinal Cord Injury.Biomedicines · 2025Review
- Current Advancements in Spinal Cord Injury Research-Glial Scar Formation and Neural Regeneration.Cells · 2023Review
- Effect of Impact Parameters on a Unilateral Contusion Model of Spinal Cord Injury in a Virtual Population of Non-Human Primates.Neurotrauma reports · 2023Article
- The biomechanical implications of neck position in cervical contusion animal models of SCI.Frontiers in neurology · 2023Review
- Seasonal Prevalence of Gastrointestinal Parasites in Macaques (Animals : an open access journal from MDPI · 2022Article
- How to generate graded spinal cord injuries in swine - tools and procedures.Disease models & mechanisms · 2021Article
- Unilateral cervical spinal cord injury induces bone loss and metabolic changes in non-human primates (Journal of orthopaedic translation · 2021Article
- Correlating Tissue Mechanics and Spinal Cord Injury: Patient-Specific Finite Element Models of Unilateral Cervical Contusion Spinal Cord Injury in Non-Human Primates.Journal of neurotrauma · 2021Article
- Comparison of the anatomical morphology of cervical vertebrae between humans and macaques: related to a spinal cord injury model.Experimental animals · 2021Article
- Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed Decompression in American Spinal Injury Association Impairment Scale Grades A, B, and C Cervical Spinal Cord Injury.Journal of neurotrauma · 2020Article
- Cell Therapeutic Strategies for Spinal Cord Injury.Advances in wound care · 2019Review
- Extent of Spinal Cord Decompression in Motor Complete (American Spinal Injury Association Impairment Scale Grades A and B) Traumatic Spinal Cord Injury Patients: Post-Operative Magnetic Resonance Imaging Analysis of Standard Operative Approaches.Journal of neurotrauma · 2019Article
- Development of a Multimodal Apparatus to Generate Biomechanically Reproducible Spinal Cord Injuries in Large Animals.Frontiers in neurology · 2019Article
- Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics.Nature protocols · 2018Article
- Restorative effects of human neural stem cell grafts on the primate spinal cord.Nature medicine · 2018Article
- Translational Challenges of Rat Models of Upper Extremity Dysfunction After Spinal Cord Injury.Topics in spinal cord injury rehabilitation · 2018Review
- Article
Corrections and comments
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Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
The development of a non-human primate (NHP) model of spinal cord injury (SCI) based on mechanical and computational modeling is described. We scaled up from a rodent model to a larger primate model using a highly controllable, friction-free, electronically-driven actuator to generate unilateral C6-C7 spinal cord injuries. Graded contusion lesions with varying degrees of functional recovery, depending upon pre-set impact parameters, were produced in nine NHPs. Protocols and pre-operative magnetic resonance imaging (MRI) were used to optimize the predictability of outcomes by matching impact protocols to the size of each animal's spinal canal, cord, and cerebrospinal fluid space. Post-operative MRI confirmed lesion placement and provided information on lesion volume and spread for comparison with histological measures. We evaluated the relationships between impact parameters, lesion measures, and behavioral outcomes, and confirmed that these relationships were consistent with our previous studies in the rat. In addition to providing multiple univariate outcome measures, we also developed an integrated outcome metric describing the multivariate cervical SCI syndrome. Impacts at the higher ranges of peak force produced highly lateralized and enduring deficits in multiple measures of forelimb and hand function, while lower energy impacts produced early weakness followed by substantial recovery but enduring deficits in fine digital control (e.g., pincer grasp). This model provides a clinically relevant system in which to evaluate the safety and, potentially, the efficacy of candidate translational therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.