Evidence map›Paper›PMID 26788548›Full record

ArticleTheScientificWorldJournal2015

Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma.

Harsh Pawar, Srinivas M Srikanth, Manoj Kumar Kashyap, Gajanan Sathe, Sandip Chavan, Mukul Singal, H C Manju, Kariyanakatte Veeraiah Veerendra Kumar, M Vijayakumar, Ravi Sirdeshmukh and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Harsh PawarInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India; Rajiv Gandhi University of Health Sciences, Bangalore 560041, India; Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India; Department of Zoology, Savitribai Phule Pune University, Ganeshkhind, Pune, Maharashtra 411007, India.
Srinivas M SrikanthInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry 605014, India.
Manoj Kumar KashyapInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0960, USA.
Gajanan SatheInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India.
Sandip ChavanInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India.
Mukul SingalGovernment Medical College and Hospital, Sector 32, Chandigarh 160030, India.
H C ManjuDepartment of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
Kariyanakatte Veeraiah Veerendra KumarDepartment of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
M VijayakumarDepartment of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
Ravi SirdeshmukhInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India.
Akhilesh PandeyMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
T S Keshava PrasadInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India; Centre of Excellence in Bioinformatics, School of Life Sciences, Pondicherry University, Pondicherry 605014, India.
Harsha GowdaInstitute of Bioinformatics, International Technology Park, Bangalore 560066, India.
Rekha V KumarDepartment of Pathology, Kidwai Memorial Institute of Oncology, Bangalore 560029, India.
Institute of Bioinformatics · INKidwai Memorial Institute of Oncology · INGovernment Medical College and Hospital · INJohns Hopkins Medicine · USPondicherry University · IN

Funding

Wellcome Trust
6 · The paper itself

Abstract

The development of esophageal squamous cell carcinoma (ESCC) is poorly understood and the major regulatory molecules involved in the process of tumorigenesis have not yet been identified. We had previously employed a quantitative proteomic approach to identify differentially expressed proteins in ESCC tumors. A total of 238 differentially expressed proteins were identified in that study including S100 calcium binding protein A9 (S100A9) as one of the major downregulated proteins. In the present study, we carried out immunohistochemical validation of S100A9 in a large cohort of ESCC patients to determine the expression and subcellular localization of S100A9 in tumors and adjacent normal esophageal epithelia. Downregulation of S100A9 was observed in 67% (n = 192) of 288 different ESCC tumors, with the most dramatic downregulation observed in the poorly differentiated tumors (99/111). Expression of S100A9 was restricted to the prickle and functional layers of normal esophageal mucosa and localized predominantly in the cytoplasm and nucleus whereas virtually no expression was observed in the tumor and stromal cells. This suggests the important role that S100A9 plays in maintaining the differentiated state of epithelium and suggests that its downregulation may be associated with increased susceptibility to tumor formation.

Indexed as

Down-RegulationAdultAgedAged, 80 and overCalgranulin BCarcinoma, Squamous CellCell NucleusCytoplasmEpithelial CellsEsophageal NeoplasmsHumansMiddle AgedCalgranulin B

Identifiers

PMID26788548
PMCPMC4691646
OpenAlexW2218571553

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.