ArticleJournal of diabetes research2016
A Novel Wistar Rat Model of Obesity-Related Nonalcoholic Fatty Liver Disease Induced by Sucrose-Rich Diet.
Article in Journal of diabetes research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose-Induced Insulin Resistance.Journal of biochemical and molecular toxicology · 2026Article
- AEROBIC EXERCISE ATTENUATES HEPATIC LIPID PEROXIDATION IN AN EXPERIMENTAL MODEL OF OBESITY-ASSOCIATED NAFLD.Arquivos de gastroenterologia · 2026Article
- Mechanisms underpinning the effect of exercise on the non-alcoholic fatty liver disease: review.EXCLI journal · 2025Review
- Dielectric and Biological Characterization of Liver Tissue in a High-Fat Diet Mouse Model.Sensors (Basel, Switzerland) · 2023Article
- A high-fat, high-fructose diet induced hepatic steatosis, renal lesions, dyslipidemia, and hyperuricemia in non-obese rats.Heliyon · 2022Article
- The Potential of the Marine MicroalgaMolecules (Basel, Switzerland) · 2022Article
- Diosgenin Ameliorates Non-alcoholic Fatty Liver Disease by Modulating the Gut Microbiota and Related Lipid/Amino Acid Metabolism in High Fat Diet-Fed Rats.Frontiers in pharmacology · 2022Article
- The Marine Microalga,Nutrients · 2021Article
- Long-term sucrose solution consumption causes metabolic alterations and affects hepatic oxidative stress in Wistar rats.Biology open · 2020Article
- Effects of dietary intake of potatoes on body weight gain, satiety-related hormones, and gut microbiota in healthy rats.RSC advances · 2019Article
- Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress.European journal of nutrition · 2019Article
- Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.International journal of obesity (2005) · 2019Article
- Can Nonfibrotic Nonalcoholic Steatohepatitis Be Effectively Identified by Supersonic Shear Imaging?Analytical cellular pathology (Amsterdam) · 2019Article
- Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not fully understood, and experimental models are an alternative to study this issue. We investigated the effects of a simple carbohydrate-rich diet on the development of obesity-related NAFLD and the impact of physical training on the metabolic abnormalities associated with this disorder. Sixty Wistar rats were randomly separated into experimental and control groups, which were fed with sucrose-enriched (18% simple carbohydrates) and standard diet, respectively. At the end of each experimental period (5, 10, 20, and 30 weeks), 6 animals from each group were sacrificed for blood tests and liver histology and immunohistochemistry. From weeks 25 to 30, 6 animals from each group underwent physical training. The experimental group animals developed obesity and NAFLD, characterized histopathologically by steatosis and hepatocellular ballooning, clinically by increased thoracic circumference and body mass index associated with hyperleptinemia, and metabolically by hyperglycemia, hyperinsulinemia, hypertriglyceridemia, increased levels of very low-density lipoprotein- (VLDL-) cholesterol, depletion of the antioxidants liver enzymes superoxide dismutase and catalase, and increased hepatic levels of malondialdehyde, an oxidative stress marker. Rats that underwent physical training showed increased high-density lipoprotein- (HDL-) cholesterol levels. In conclusion, a sucrose-rich diet induced obesity, insulin resistance, oxidative stress, and NAFLD in rats.
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