ArticleIranian journal of otorhinolaryngology2015
Montelukast in Adenoid Hypertrophy: Its Effect on Size and Symptoms.
Article in Iranian journal of otorhinolaryngology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Non-pharmacological therapy for pediatric adenoid hypertrophy: a systematic review and network meta-analysis.Frontiers in pediatrics · 2026Pooled it
- Er:YAG laser for snoring: a systemic review and meta-analysis.Lasers in medical science · 2020Pooled it
- Montelukast for Children with Obstructive Sleep Apnea: Results of a Double-Blind, Randomized, Placebo-Controlled Trial.Annals of the American Thoracic Society · 2016Trial
- Intranasal Corticosteroids and Oral Montelukast for Paediatric Obstructive Sleep Apnoea: A Systematic Review.Pharmaceutics · 2025Review
- Management of obstructive sleep apnea-hypopnea syndrome in children: what is the role of orthodontics? A scoping review.Sleep & breathing = Schlaf & Atmung · 2025Article
- Effect of Combination Montelukast and Nasal Mometasone on Childhood Adenoid Hypertrophy.Iranian journal of otorhinolaryngology · 2024Article
- A Clinical Study of Persistent Adenoid and Its Secondary Effect.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The First-Line Approach in Children with Obstructive Sleep Apnea Syndrome (OSA).Journal of clinical medicine · 2023Review
- The Role of Montelukast Sodium in Children with Adenoid Hypertrophy - A Comparative Study.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- 150th Anniversary of global adenoid investigations: unanswered questions and unsolved problems.Frontiers in pediatrics · 2023Review
- Effects of oral cysteine leukotriene receptor antagonist-montelukast on adenoid lymphoid tissue: a histopathological study under light microscope.Frontiers in pharmacology · 2023Article
- Article
- Down-regulation of anti-inflammatory TIPE2 may aggravate adenoidal hypertrophy in children.FEBS open bio · 2020Article
- The cost-effectiveness analysis of drug therapy versus surgery for symptomatic adenoid hypertrophy by a Markov model.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Non-surgical treatment of obstructive sleep apnea syndrome.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018Review
- Adenoidectomy in Children: What Is the Evidence and What Is its Role?Current otorhinolaryngology reports · 2018Review
- Observational
- Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy.Pakistan journal of medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdenotonsillar hypertrophy (AH) is considered the most common cause of upper respiratory tract obstruction among children. It results in a spectrum of symptoms from mouth breathing, nasal obstruction, hyponasal speech, snoring, and obstructive sleep apnea (OSA) to growth failure and cardiovascular morbidity. Adenotonsillectomy is a typical strategy for patients with AH, but may lead to serious complications such as bleeding (4-5%) and postoperative respiratory compromise (27%), especially among young children, as well as recurrence of adenoid tissue (10-20%). Thus, non-surgical therapies have attracted considerable attention as an alternative strategy. The inflammatory mechanism proposed for AH has lead to the use of anti-inflammatory drugs to manage this condition. The present study aimed to evaluate the effect of chewable tablets of montelukast, a cysteinyl- leukotriene receptor antagonist, in children with AH. MATERIALS AND
methodsSixty children between the ages of 4-12 years with >75% choanal obstruction on primary nasal endoscopy were recruited in this randomized, placebo-controlled trial and randomly divided into two groups. The study group was treated with montelukast 5 mg daily for 12 weeks while the control group received matching placebo for the same period of time. A questionnaire was completed by each child's parent/guardian to assess the severity of sleep discomfort, snoring, and mouth breathing before and after the intervention.
resultsAdenoid size decreased in 76% of the study group compared with 3% of the placebo group after 12 weeks. A statically significant improvement was observed in the study group compared with the placebo group in terms of sleep discomfort, snoring, and mouth breathing. The symptoms average total score dropped from 7.7 to 3.3 in the study group, while in the placebo group the total score changed from 7.4 to 6.7.
conclusionMontelukast chewable tablets achieved a significant reduction in adenoid size and improved the related clinical symptoms of AH and can therefore be considered an effective alternative to surgical treatment in children with adenoid hypertrophy.
Indexed as
Identifiers
26788489PMC4706629W1948386869What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.