ArticleBiochemistry research international2015
Distribution of Phenolic Contents, Antidiabetic Potentials, Antihypertensive Properties, and Antioxidative Effects of Soursop (Annona muricata L.) Fruit Parts In Vitro.
Article in Biochemistry research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 84 citations in OpenAlex.
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- Effect of Enzymatic Biotransformation on the Hypotensive Potential of Red Grape Pomace Extract.Foods (Basel, Switzerland) · 2023Article
- Soursop (Foods (Basel, Switzerland) · 2023Review
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- Preservation ofTropical life sciences research · 2022Article
- Pharmacological Activities of Soursop (Molecules (Basel, Switzerland) · 2022Review
- Inhibitory Effects of Roseoside and Icariside E4 Isolated from a Natural Product Mixture (No-ap) on the Expression of Angiotensin II Receptor 1 and Oxidative Stress in Angiotensin II-Stimulated H9C2 Cells.Molecules (Basel, Switzerland) · 2019Article
- Protective potentials ofJournal of carcinogenesis · 2019Article
- Antihypertensive Effect of Ethanolic Extract fromOxidative medicine and cellular longevity · 2018Article
- Identification of Antidiabetic Compounds from Polyphenolic-rich Fractions ofPharmacognosy researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Soursop fruit has been used in folklore for the management of type-2 diabetes and hypertension with limited information on the scientific backing. This study investigated the effects of aqueous extracts (1 : 100 w/v) of Soursop fruit part (pericarp, pulp, and seed) on key enzymes linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension [angiotensin-I converting enzyme (ACE)]. Radicals scavenging and Fe(2+) chelation abilities and reducing property as well as phenolic contents of the extracts were also determined. Our data revealed that the extracts inhibited α-amylase and α-glucosidase and ACE activities dose-dependently. The effective concentration of the extract causing 50% antioxidant activity (EC50) revealed that pericarp extract had the highest α-amylase (0.46 mg/mL), α-glucosidase (0.37 mg/mL), and ACE (0.03 mg/mL) inhibitory activities while the seed extract had the least [α-amylase (0.76 mg/mL); α-glucosidase (0.73 mg/mL); and ACE (0.20 mg/mL)]. Furthermore, the extracts scavenged radicals, reduced Fe(3+) to Fe(2+), and chelated Fe(2+). The phenolic contents in the extracts ranged from 85.65 to 560.21 mg/100 g. The enzymes inhibitory and antioxidants potentials of the extracts could be attributed to their phenolic distributions which could be among the scientific basis for their use in the management of diabetes and hypertension. However, the pericarp appeared to be most promising.
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Registered trials
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