ArticleJournal of clinical movement disorders2015
Isolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review.
Article in Journal of clinical movement disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Cranial Tremors in Essential Tremor: Prevalence, Anatomic Distribution and Predictors of Occurrence.Movement disorders clinical practice · 2025Article
- From Practice to Public Health: Broadening Neuropsychology's Reach & Value-An Introduction to the National Academy of Neuropsychology's 2022 Annual Conference Special Issue.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Longitudinal study of clinical and neurophysiological features in essential tremor.European journal of neurology · 2023Article
- Bayesian Interpretation of Essential Tremor Plus.Journal of clinical neurology (Seoul, Korea) · 2022Review
- Classification of vocal tremor using updated consensus-based tremor classification criteria.Laryngoscope investigative otolaryngology · 2021Article
- Tremor Syndromes: An Updated Review.Frontiers in neurology · 2021Review
- Oral propranolol for treatment of the subgroups of essential tremor: a systematic review and meta-analysis protocol.BMJ open · 2020Article
- Isolated Voice Tremor: A Clinical Variant of Essential Tremor or a Distinct Clinical Phenotype?Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Review
- Defining differences in patient characteristics between spasmodic dysphonia and laryngeal tremor.The Laryngoscope · 2019Article
- Characterizing the Normative Voice Tremor Frequency in Essential Vocal Tremor.JAMA otolaryngology-- head & neck surgery · 2018Observational
- Outcomes of Onabotulinum Toxin A Treatment for Adductor Spasmodic Dysphonia and Laryngeal Tremor.JAMA otolaryngology-- head & neck surgery · 2018Article
- Speech-Language Pathology Evaluation and Management of Hyperkinetic Disorders Affecting Speech and Swallowing Function.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Approach to a tremor patient.Annals of Indian Academy of NeurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEssential tremor (ET) is a common condition associated with significant physical and psychosocial disability. "Classic" ET is a clinical syndrome of action tremor in the upper limbs and less commonly the head, jaw, voice, trunk, or lower limbs. Current diagnostic criteria for ET exclude isolated vocal tremor (IVT). Failure to recognize IVT as a form of ET may contribute to misdiagnosis and missed opportunities for treatment.
methodsWe conducted a retrospective review of cases referred for voice disturbance. Patients with a primary diagnosis of vocal tremor were included while those with a diagnosis of spasmodic dysphonia where excluded.
results19 cases of vocal tremor were identified, of which 17 patients (89%) were female. The average age of vocal symptom onset was 64 (SD 8.0) and patients had been symptomatic an average of 6 years (SD 4) at their initial visit. 8 patients had IVT while 11 also had evidence of subtle head or limb tremor. 8 patients (42%) had a family history of ET, with vocal tremor specifically identified in 5 of those cases (26%). 11 patients (58%) noted transient tremor improvement after alcohol consumption. Primidone and propranolol were the most common medications prescribed to these patients prior to consultation. 7 patients were given a trial of 1 gm of sodium oxybate in the office as part of a clinical trial, with at least mild improvement in vocal tremor noted by qualitative assessment.
conclusionsET may present as vocal tremor with little or no associated limb tremor. It may be a more common manifestation of ET in women. A family history of tremor and improvement in tremor after consuming alcohol can often be elicited on history. We propose that IVT may be part of the spectrum of ET.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.