Evidence map›Paper›PMID 26788077›Full record

ArticleArchives of medical science : AMS2015

Brain-derived neurotrophic factor and its clinical implications.

Siresha Bathina, Undurti N Das

4 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 693 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
693citing papers in PubMed, 12 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04899206 withdrawnnot on this mapstarted 2021, after this paper: background citation

Angiotensin agents and reduction of the prescription of antidepressant drugs: a retrospective cohort study using real-world data

Typeobservational_patient_registrySponsorSebastian VidelaRan2021 to 2025Enrolled0ConditionsACE Inhibitors, ARB, Hypertension, DepressionArmsWith an Antidepressant Drug, Without an Antidepressant Drug
NCT05138016 nacompletednot on this mapstarted 2021, after this paper: background citation

Effects of Soft Robotic Exosuit on Exercise Capacity, Biomakers of Neuroplasticity, and Motor Learning After Stroke

TypeinterventionalSponsorBoston University Charles River CampusRan2021 to 2023Enrolled11ConditionsStrokeArmsSoft exosuit, No Soft exosuit
NCT05735405 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Priming Effects of Aerobic Exercise on Cognitive Training of Patients With Ischemic and Hemorrhagic Stroke

TypeinterventionalSponsorFondazione Don Carlo Gnocchi ETSRan2022 to 2023Enrolled30ConditionsIschemic Stroke, Hemorrhagic StrokeArmsNeuropsychological evaluation, BDNF evaluation, Pedaling as a moderate intensity aerobic exercise, Cognitive Training, VO2 assessment
NCT06097780 phase3unknown statusnot on this mapstarted 2024, after this paper: background citation

Phase III Efficacy and Safety of NestaCell® in Moderated Huntington's Disease

TypeinterventionalSponsorAzidus BrasilRan2024 to 2026Enrolled120ConditionsHuntington DiseaseArmsNestaCell®
3 · Its place in the literature

Who cites it

693 citing papers in PubMed, 12 syntheses or guidelines pooled it, 1,276 citations in OpenAlex.

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633 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Siresha BathinaBio-Science Research Center, Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India.
Undurti N DasBio-Science Research Center, Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India; UND Life Sciences, USA.
Gujarat Vidyapith · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) plays an important role in neuronal survival and growth, serves as a neurotransmitter modulator, and participates in neuronal plasticity, which is essential for learning and memory. It is widely expressed in the CNS, gut and other tissues. BDNF binds to its high affinity receptor TrkB (tyrosine kinase B) and activates signal transduction cascades (IRS1/2, PI3K, Akt), crucial for CREB and CBP production, that encode proteins involved in β cell survival. BDNF and insulin-like growth factor-1 have similar downstream signaling mechanisms incorporating both p-CAMK and MAPK that increase the expression of pro-survival genes. Brain-derived neurotrophic factor regulates glucose and energy metabolism and prevents exhaustion of β cells. Decreased levels of BDNF are associated with neurodegenerative diseases with neuronal loss, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis and Huntington's disease. Thus, BDNF may be useful in the prevention and management of several diseases including diabetes mellitus.

Indexed as

Alzheimer's diseasebrain-derived neurotrophic factordiabetes mellitusneurotransmissionsignal transductionβ cell

Identifiers

PMID26788077
PMCPMC4697050
OpenAlexW2266543467

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.