ArticleArchives of medical science : AMS2015
Ear lobe crease: a marker of coronary artery disease?
Article in Archives of medical science : AMS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07427745 (PRESENCE OF FRANK'S SIGN), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Presence of frank's sign: a comparative evaluation in smokers and non-smokers
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagonal earlobe crease (Frank's sign) and increased risk of cerebrovascular diseases: review of the literature and implications for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Pooled it
- TyHGB combined with diagonal earlobe crease and traditional risk factors for constructing a diagnostic model of coronary heart disease.Lipids in health and disease · 2026Article
- Diagnostic value of the diagonal earlobe crease in combination with lipoprotein(a) in coronary heart disease.Scientific reports · 2025Article
- Prevalence of Frank's sign in healthy young individuals, morphological characteristics, and its association with family history of chronic disease.Forensic science, medicine, and pathology · 2024Article
- Association of Diagonal Earlobe Crease with Risk of Atrial Fibrillation in Stable Patients with Coronary Artery Disease.Journal of clinical medicine · 2024Article
- Relationship between Earlobe Crease and Anatomical Severity of Coronary Artery Disease in ST-segment Elevation Myocardial Infarction.Internal medicine (Tokyo, Japan) · 2024Article
- Association of advanced glycation end products with ear lobe crease: A cross-sectional study.Journal of diabetes · 2024Article
- Dermatological manifestations of cardiac conditions.The British journal of cardiology · 2022Article
- Diagonal earlobe crease and long-term survival after myocardial infarction.BMC cardiovascular disorders · 2021Article
- What do Steven Spielberg, Mel Gibson and Emperor Hadrian have in common? Frank's sign and the link with coronary artery disease.Oxford medical case reports · 2021Article
- The Histological Basis of Frank's Sign.Head and neck pathology · 2021Article
- Adropin and Irisin Deficiencies Are Associated With Presence of Diagonal Earlobe Crease in CAD Patients.Frontiers in cardiovascular medicine · 2021Article
- Prevalence of the Frank's sign by aetiopathogenic stroke subtype: A prospective analysis.PloS one · 2021Article
- Value of Transverse Groove on the Earlobe and Hair Growth on the Ear to Predict the Risk for Coronary Artery Disease and Its Severity among Iranian Population, in Tehran City.Galen medical journal · 2020Article
- On the association between earlobe crease and the carotid intima-media thickness: A population-based study.Heliyon · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ear lobe crease (ELC) has been defined as a deep wrinkle that extends backwards from the tragus to the auricle. It has been proposed that ELC is a predictor of coronary artery disease (CAD). In this review, we consider the possible association between ELC and CAD. Our aim is to systematically address all the relevant evidence in this field. There are many studies that support an association between ELC and CAD. However, other studies did not find such an association. A recent meta-analysis supports the hypothesis that ELC could be a marker of CAD. However, several limitations raise doubts as to whether we should accept this link.
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