ReviewInternational journal of endocrinology2015
Role of FTO in Adipocyte Development and Function: Recent Insights.
Review in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- FTO-dependent m6A methylation mediates gestational diabetes mellitus-induced offspring cardiac senescent hypertrophy and dysfunction.iScience · 2026Article
- Sec14L6 is a phosphoinositide transporter that regulates phosphoinositide homeostasis and biogenesis of lipid droplets.Nature communications · 2025Article
- White Adipocyte Stem Cell Expansion Through Infant Formula Feeding: New Insights into Epigenetic Programming Explaining the Early Protein Hypothesis of Obesity.International journal of molecular sciences · 2025Review
- NEFA Dynamics in Adults With Severe Obesity and Insulin Resistance: No Coupling to the rs9939609Journal of the Endocrine Society · 2023Article
- Review
- RUNX1T1 function in cell fate.Stem cell research & therapy · 2022Review
- The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis.International journal of molecular sciences · 2022Article
- Breastfeeding moderates the relationship betweenObesity science & practice · 2022Article
- Emerging Roles of FTO in Neuropsychiatric Disorders.BioMed research international · 2022Review
- Fat mass and obesity-associated protein regulates tumorigenesis of arecoline-promoted human oral carcinoma.Cancer medicine · 2021Article
- Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- RNAs and RNA-Binding Proteins in Immuno-Metabolic Homeostasis and Diseases.Frontiers in cardiovascular medicine · 2019Review
- Molecular Biomarkers for Gestational Diabetes Mellitus.International journal of molecular sciences · 2018Review
- Mapping novel genetic loci associated with female liver weight variations using Collaborative Cross mice.Animal models and experimental medicine · 2018Article
- FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.Journal of lipid research · 2018Article
- Characterization of RUNX1T1, an Adipogenesis Regulator in Ovine Preadipocyte Differentiation.International journal of molecular sciences · 2018Article
- FTO demethylase activity is essential for normal bone growth and bone mineralization in mice.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Identification of Candidate Genes and Regulatory Factors Underlying Intramuscular Fat Content Through Longissimus Dorsi Transcriptome Analyses in Heavy Iberian Pigs.Frontiers in genetics · 2018Article
- Critical Enzymatic Functions of FTO in Obesity and Cancer.Frontiers in endocrinology · 2018Review
- FTO associations with obesity and telomere length.Journal of biomedical science · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2007, FTO was identified as the first genome-wide association study (GWAS) gene associated with obesity in humans. Since then, various animal models have served to establish the mechanistic basis behind this association. Many earlier studies focussed on FTO's effects on food intake via central mechanisms. Emerging evidence, however, implicates adipose tissue development and function in the causal relationship between perturbations in FTO expression and obesity. The purpose of this mini review is to shed light on these new studies of FTO function in adipose tissue and present a clearer picture of its impact on obesity susceptibility.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.