Analysis of functional polymorphisms in apoptosis-related genes in primary open angle glaucoma.

Ewald Lindner, Wilfried Glatz, Christoph Schwab, Yosuf El-Shabrawi, Georg Mossböck

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In one paragraph

Article in Molecular vision, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 · What the graph read from it

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1 citing paper in PubMed.

Postoperative Pain after Different Transscleral Laser Cyclophotocoagulation Procedures.International journal of environmental research and public health · 2023
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5 · Who and what money

Authors and funding

5 authors.

Ewald LindnerDepartment of Ophthalmology, Medical University of Graz, Austria.

Wilfried GlatzDepartment of Ophthalmology, Medical University of Graz, Austria.

Christoph SchwabDepartment of Ophthalmology, Medical University of Graz, Austria.

Yosuf El-ShabrawiDepartment of Ophthalmology, Medical University of Graz, Austria.

Georg MossböckDepartment of Ophthalmology, Medical University of Graz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGlaucoma is a disease with high heritability in which the degradation of retinal ganglion cells occurs via apoptosis. Therefore, we investigated the role of four functional apoptosis-related gene variants (Akt1 rs1130233, Bax rs4645878, Fas rs223476, and FasL rs763110) in patients with primary open angle glaucoma.

methods334 patients with primary open angle glaucoma and 334 controls were recruited for this case-control study. The main outcome measures were genotype distribution and allelic frequencies determined with PCR.

resultsAfter adjustment for multiple testing, no significant difference in either the genotype distribution or the allelic frequencies of any investigated gene variant was found.

conclusionsOur findings indicate that the investigated gene polymorphisms are unlikely to be major risk factors for primary open angle glaucoma in Caucasian patients.

Indexed as

Polymorphism, Single NucleotideAgedAged, 80 and overApoptosisbcl-2-Associated X ProteinCase-Control StudiesFas Ligand Proteinfas ReceptorFemaleGene FrequencyGenetic Association StudiesGenotypeGlaucoma, Open-AngleHumansMaleMiddle AgedAKT1 protein, humanBAX protein, humanbcl-2-Associated X ProteinFASLG protein, humanFas Ligand ProteinFAS protein, humanfas ReceptorProto-Oncogene Proteins c-akt

Identifiers

PMID26788026

PMCPMC4704768

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