ArticleJournal of food science and technology2016
Relative bioavailability of folate from the traditional food plant Moringa oleifera L. as evaluated in a rat model.
Article in Journal of food science and technology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 59 citations in OpenAlex.
- Medicinal utilization and nutritional properties of drumstick (Food science & nutrition · 2024Review
- Recent Advances in Drumstick (Antioxidants (Basel, Switzerland) · 2022Review
- The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in theFrontiers in aging neuroscience · 2022Article
- Scribbling the Cat: A Case of the "Miracle" Plant,Plants (Basel, Switzerland) · 2019Review
- The effect of silver nitrate on micropropagation ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2019Article
- Application of Moringa (Animals : an open access journal from MDPI · 2019Review
- Article
- Phytochemicals of Moringa oleifera: a review of their nutritional, therapeutic and industrial significance.3 Biotech · 2016Review
- A Review of the Phytochemical and Pharmacological Characteristics ofJournal of pharmacy & bioallied sciencesReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Moringa oleifera is an affordable and rich source of dietary folate. Quantification of folate by HPLC showed that 5-formyl-5,6,7,8-tetrahydrofolic acid (502.1 μg/100 g DW) and 5,6,7,8-tetrahydrofolic acid (223.9 μg/100 g DW) as the most dominant forms of folate in M. oleifera leaves. The bioavailability of folate and the effects of folate depletion and repletion on biochemical and molecular markers of folate status were investigated in Wistar rats. Folate deficiency was induced by keeping the animals on a folate deficient diet with 1 % succinyl sulfathiazole (w/w). After the depletion period, animals were repleted with different levels of folic acid and M. oleifera leaves as a source of folate. Feeding the animals on a folate deficient diet for 7 weeks caused a significant (3.4-fold) decrease in serum folate content, compared to non-depleted control animals. Relative bioavailability of folate from dehydrated leaves of M. oleifera was 81.9 %. During folate depletion and repletion, no significant changes in liver glycine N-methyl transferase and 5-methyltetrahydrofolate-homocysteine methyltransferase expression were recorded. In RDA calculations, only 50 % of natural folate is assumed to be bioavailable. Therefore, the bioavailability of folate from Moringa is much higher, suggesting that M. oleifera based food can be used as a significant source of folate.
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Registered trials
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