ArticleProceedings of the National Academy of Sciences of the United States of America2016
X-ray structure of the MMTV-A nucleosome core.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Evaluating high-fidelity CRISPR-Cas nucleases in nucleosomal contexts using a quantitative framework.Frontiers in genome editing · 2026Article
- Defining transcription factor nucleosome binding with Pioneer-seq.PLoS genetics · 2025Article
- High-Resolution Cryo-EM Analyses of Nucleosomes.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Poly(dA:dT) Tracts Differentially Modulate Nucleosome Remodeling Activity of RSC and ISW1a Complexes, Exerting Tract Orientation-Dependent and -Independent Effects.International journal of molecular sciences · 2023Article
- Developing Community Resources for Nucleic Acid Structures.Life (Basel, Switzerland) · 2022Review
- Structures of Native-like Nucleosomes: One Step Closer toward Understanding the Structure and Function of Chromatin.Journal of molecular biology · 2021Review
- Succinylation of H3K122 destabilizes nucleosomes and enhances transcription.EMBO reports · 2021Article
- Remodeler Catalyzed Nucleosome Repositioning: Influence of Structure and Stability.International journal of molecular sciences · 2020Review
- CENP-A nucleosome-a chromatin-embedded pedestal for the centromere: lessons learned from structural biology.Essays in biochemistry · 2020Review
- Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation.Biochemistry · 2020Article
- The human telomeric nucleosome displays distinct structural and dynamic properties.Nucleic acids research · 2020Article
- Nucleosome destabilization by nuclear non-coding RNAs.Communications biology · 2020Article
- Article
- 5-Formylcytosine organizes nucleosomes and forms Schiff base interactions with histones in mouse embryonic stem cells.Nature chemistry · 2018Article
- Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections.Nucleic acids research · 2018Article
- Cryo-EM structure of the nucleosome containing theOpen biology · 2018Article
- Site-Specific Disulfide Crosslinked Nucleosomes with Enhanced Stability.Journal of molecular biology · 2018Article
- A DNA structural alphabet provides new insight into DNA flexibility.Acta crystallographica. Section D, Structural biology · 2018Article
- Article
- Contributions of Sequence to the Higher-Order Structures of DNA.Biophysical journal · 2017Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The conformation of DNA bound in nucleosomes depends on the DNA sequence. Questions such as how nucleosomes are positioned and how they potentially bind sequence-dependent nuclear factors require near-atomic resolution structures of the nucleosome core containing different DNA sequences; despite this, only the DNA for two similar α-satellite sequences and a sequence (601) selected in vitro have been visualized bound in the nucleosome core. Here we report the 2.6-Å resolution X-ray structure of a nucleosome core particle containing the DNA sequence of nucleosome A of the 3'-LTR of the mouse mammary tumor virus (147 bp MMTV-A). To our knowledge, this is the first nucleosome core particle structure containing a promoter sequence and crystallized from Mg(2+) ions. It reveals sequence-dependent DNA conformations not seen previously, including kinking into the DNA major groove.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.