ArticleProceedings of the National Academy of Sciences of the United States of America2016
Assessment of fight outcome is needed to activate socially driven transcriptional changes in the zebrafish brain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 120 citations in OpenAlex.
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- NMDAR-CaMKII Pathway as a Central Regulator of Aggressiveness: Evidence from Transcriptomic and Metabolomic Analysis in Swimming CrabsInternational journal of molecular sciences · 2024Article
- Trait sensitivity to stress and cognitive bias processes in fish: A brief overview.Personality neuroscience · 2024Review
- Transcriptomic responses to location learning by honeybee dancers are partly mirrored in the brains of dance-followers.Proceedings. Biological sciences · 2023Article
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- Mating experiences with the same partner enhanced mating activities of naïve male medaka fish.Scientific reports · 2022Article
- Convergence on reduced aggression through shared behavioral traits in multiple populations of Astyanax mexicanus.BMC ecology and evolution · 2022Article
- Alternative splicing plays key roles in response to stress across different stages of fighting in the fish Betta splendens.BMC genomics · 2022Article
- Transcriptomic underpinnings of high and low mirror aggression zebrafish behaviours.BMC biology · 2022Article
- Dynamic neurogenomic responses to social interactions and dominance outcomes in female paper wasps.PLoS genetics · 2021Article
- Effects of air pollution exposure on social behavior: a synthesis and call for research.Environmental health : a global access science source · 2021Review
- Experimental competition induces immediate and lasting effects on the neurogenome in free-living female birds.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Family-effects in the epigenomic response of red blood cells to a challenge test in the European sea bass (Dicentrarchus labrax, L.).BMC genomics · 2021Article
- Human-Wildlife Coexistence in Urban Wildlife Management: Insights from Nonlethal Predator Management and Rodenticide Bans.Animals : an open access journal from MDPI · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group living animals must be able to express different behavior profiles depending on their social status. Therefore, the same genotype may translate into different behavioral phenotypes through socially driven differential gene expression. However, how social information is translated into a neurogenomic response and what are the specific cues in a social interaction that signal a change in social status are questions that have remained unanswered. Here, we show for the first time, to our knowledge, that the switch between status-specific neurogenomic states relies on the assessment of fight outcome rather than just on self- or opponent-only assessment of fighting ability. For this purpose, we manipulated the perception of fight outcome in male zebrafish and measured its impact on the brain transcriptome using a zebrafish whole genome gene chip. Males fought either a real opponent, and a winner and a loser were identified, or their own image on a mirror, in which case, despite expressing aggressive behavior, males did not experience either a victory or a defeat. Massive changes in the brain transcriptome were observed in real opponent fighters, with losers displaying both a higher number of differentially expressed genes and of coexpressed gene modules than winners. In contrast, mirror fighters expressed a neurogenomic state similar to that of noninteracting fish. The genes that responded to fight outcome included immediate early genes and genes involved in neuroplasticity and epigenetic modifications. These results indicate that, even in cognitively simple organisms such as zebrafish, neurogenomic responses underlying changes in social status rely on mutual assessment of fighting ability.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.