ArticleProceedings of the National Academy of Sciences of the United States of America2016
Diminished viral replication and compartmentalization of hepatitis C virus in hepatocellular carcinoma tissue.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Hepatitis Viruses Infection Up-Regulating Fibrosis Signals in Hepatocellular Carcinoma.Biomedicines · 2026Article
- Genome-wide identification, expression analysis of the R2R3-MYB gene family and their potential roles under cold stress in Prunus sibirica.BMC genomics · 2024Article
- Genome-wide identification, expression analysis, and potential roles under low-temperature stress of bHLH gene family inFrontiers in plant science · 2023Article
- A Novel Nomogram Model to Predict the Recurrence-Free Survival and Overall Survival of Hepatocellular Carcinoma.Frontiers in oncology · 2022Article
- GOLT1B Activation in Hepatitis C Virus-Infected Hepatocytes Links ER Trafficking and Viral Replication.Pathogens (Basel, Switzerland) · 2021Article
- Retinoic Acid-Inducible Gene I-Like Receptors Activate Snail To Limit RNA Viral Infections.Journal of virology · 2021Article
- Hepatitis D Virus and Hepatocellular Carcinoma.Viruses · 2021Review
- Chitinase 3-like 1 is a profibrogenic factor overexpressed in the aging liver and in patients with liver cirrhosis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Genetic Variability in Patients with HCV-Related Hepatocellular Carcinoma.Infection and drug resistance · 2021Article
- Molecular Signature and Immune Landscape of HCV-Associated Hepatocellular Carcinoma (HCC): Differences and Similarities with HBV-HCC.Journal of hepatocellular carcinoma · 2021Article
- Review
- The Significance of HCV Viral Load in the Incidence of HCC: a Correlation Between Mir-122 and CCL2.Journal of gastrointestinal cancer · 2020Review
- Hepatitis E Virus Shows More Genomic Alterations in Cell Culture than In Vivo.Pathogens (Basel, Switzerland) · 2019Article
- Article
- Review
- Molecular Signature and Mechanisms of Hepatitis D Virus-Associated Hepatocellular Carcinoma.Molecular cancer research : MCR · 2018Article
- Role of caveolin-1 in hepatocellular carcinoma arising from non-alcoholic fatty liver disease.Cancer science · 2018Article
- Infection with hepatitis C virus depends on TACSTD2, a regulator of claudin-1 and occludin highly downregulated in hepatocellular carcinoma.PLoS pathogens · 2018Article
- Oncoprotein Stathmin Modulates Sensitivity to Apoptosis in Hepatocellular Carcinoma Cells During Hepatitis C Viral Replication.Journal of cell death · 2018Article
- Viral hepatitis and liver cancer.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Analysis of hepatitis C virus (HCV) replication and quasispecies distribution within the tumor of patients with HCV-associated hepatocellular carcinoma (HCC) can provide insight into the role of HCV in hepatocarcinogenesis and, conversely, the effect of HCC on the HCV lifecycle. In a comprehensive study of serum and multiple liver specimens from patients with HCC who underwent liver transplantation, we found a sharp and significant decrease in HCV RNA in the tumor compared with surrounding nontumorous tissues, but found no differences in multiple areas of control non-HCC cirrhotic livers. Diminished HCV replication was not associated with changes in miR-122 expression. HCV genetic diversity was significantly higher in livers containing HCC compared with control non-HCC cirrhotic livers. Tracking of individual variants demonstrated changes in the viral population between tumorous and nontumorous areas, the extent of which correlated with the decline in HCV RNA, suggesting HCV compartmentalization within the tumor. In contrast, compartmentalization was not observed between nontumorous areas and serum, or in controls between different areas of the cirrhotic liver or between liver and serum. Our findings indicate that HCV replication within the tumor is restricted and compartmentalized, suggesting segregation of specific viral variants in malignant hepatocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.