ArticleAntimicrobial agents and chemotherapy2016
Novel Genes Related to Ceftriaxone Resistance Found among Ceftriaxone-Resistant Neisseria gonorrhoeae Strains Selected In Vitro.
Article in Antimicrobial agents and chemotherapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- The Role of the Hfq Protein in Bacterial Resistance to Antibiotics: A Narrative Review.Microorganisms · 2025Review
- Rolling the evolutionary dice:Microbiology spectrum · 2024Article
- Dissemination and genome analysis of high-level ceftriaxone-resistantEmerging microbes & infections · 2022Article
- Tolerance to Ceftriaxone inAntibiotics (Basel, Switzerland) · 2022Article
- Review
- Article
- Evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through short sequence duplications.PloS one · 2022Article
- The contribution of nano-based strategies in overcoming ceftriaxone resistance: a literature review.Pharmacology research & perspectives · 2021Review
- Point-by-Point Progress: Gonorrhea Point of Care Tests.Expert review of molecular diagnostics · 2020Article
- Producing polished prokaryotic pangenomes with the Panaroo pipeline.Genome biology · 2020Article
- Comparative Proteomics of Extended-Spectrum Cephalosporin-ResistantFrontiers in microbiology · 2020Article
- Genomic epidemiology and population structure of Neisseria gonorrhoeae from remote highly endemic Western Australian populations.BMC genomics · 2018Article
- Antimicrobial Consumption and Susceptibility ofFrontiers in medicine · 2018Article
- Evolution of Antibiotic Resistance without Antibiotic Exposure.Antimicrobial agents and chemotherapy · 2017Article
- Antibiotic Susceptibility Monitoring of Neisseria gonorrhoeae in Bacolod City, Philippines.Tropical medicine and infectious disease · 2017Article
- Ceftriaxone-Resistant Neisseria gonorrhoeae Isolates (2010 to 2014) in France Characterized by Using Whole-Genome Sequencing.Antimicrobial agents and chemotherapy · 2016Article
- Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins.Antibiotics (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of ceftriaxone-resistantNeisseria gonorrhoeaeis currently a global public health concern. However, the mechanism of ceftriaxone resistance is not yet fully understood. To investigate the potential genes related to ceftriaxone resistance inNeisseria gonorrhoeae, we subcultured six gonococcal strains with increasing concentrations of ceftriaxone and isolated the strains that became resistant. After analyzing several frequently reported genes involved in ceftriaxone resistance, we found only a single mutation inpenA(A501V). However, differential analysis of the genomes and transcriptomes between pre- and postselection strains revealed many other mutated genes as well as up- and downregulated genes. Transformation of the mutatedpenAgene into nonresistant strains increased the MIC between 2.0- and 5.3-fold, and transformation of mutatedftsXincreased the MIC between 3.3- and 13.3-fold. Genes encoding the ABC transporters FarB, Tfq, Hfq, and ExbB were overexpressed, whilepilM,pilN, andpilQwere downregulated. Furthermore, the resistant strain developed cross-resistance to penicillin and cefuroxime, had an increased biochemical metabolic rate, and presented fitness defects such as prolonged growth time and downregulated PilMNQ. In conclusion, antimicrobial pressure could result in the emergence of ceftriaxone resistance, and the evolution of resistance ofNeisseria gonorrhoeaeto ceftriaxone is a complicated process at both the pretranscriptional and posttranscriptional levels, involving several resistance mechanisms of increased efflux and decreased entry.
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