ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
B7-H3 increases thymidylate synthase expression via the PI3k-Akt pathway.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Targeting cytokine and chemokine signaling pathways for enhancing chemo-sensitivity in colorectal cancer.Cell communication and signaling : CCS · 2025Review
- The relevance of B7-H3 and tumor-associated macrophages in the tumor immune microenvironment of solid tumors: recent advances.American journal of translational research · 2025Review
- Non-immune functions of B7-H3: bridging tumor cells and the tumor vasculature.Frontiers in oncology · 2024Review
- Article
- Programmed death ligand 1 signals in cancer cells.Nature reviews. Cancer · 2022Review
- B7-H3, Negatively Regulated by miR-128, Promotes Colorectal Cancer Cell Proliferation and Migration.Cell biochemistry and biophysics · 2021Article
- The expression of B7-H3 isoforms in newly diagnosed glioblastoma and recurrence and their functional role.Acta neuropathologica communications · 2021Article
- Clinical Insights Into Novel Immune Checkpoint Inhibitors.Frontiers in pharmacology · 2021Review
- B7-H3, a checkpoint molecule, as a target for cancer immunotherapy.International journal of biological sciences · 2020Review
- Clinical and Prognostic Relevance of B7-H3 and Indicators of Glucose Metabolism in Colorectal Cancer.Frontiers in oncology · 2020Article
- B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma.Laboratory investigation; a journal of technical methods and pathology · 2019Article
- p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance.Scientific reports · 2019Article
- The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells.Scientific reports · 2019Article
- Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review).International journal of oncology · 2018Review
- B7H3 As a Promoter of Metastasis and Promising Therapeutic Target.Frontiers in oncology · 2018Review
- B7-H3 promotes gastric cancer cell migration and invasion.Oncotarget · 2017Article
- Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression.Oncotarget · 2017Article
- B7-H3 participates in the development of Asthma by augmentation of the inflammatory response independent of TLR2 pathway.Scientific reports · 2017Article
- Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma.Cancer research · 2016Article
- Tumor cell-intrinsic PD-L1 promotes tumor-initiating cell generation and functions in melanoma and ovarian cancer.Signal transduction and targeted therapyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B7-H3, a member of the B7 family, has been reported to be highly expressed in colorectal cancer and is associated with poor prognosis and overall survival. In this study, we found that overexpression of B7-H3 protected SW80 and HCT8 cells from 5-fluorouracil (5-FU) using CCK-8 assays by inducing resistance to 5-FU chemotherapy. Further investigation has revealed elevated expression of thymidylate synthase (TS) and upregulation of the PI3-kinase (PI3K)/Akt pathway in B7-H3 overexpressing cells. The effects of B7-H3 on activation of the PI3K/Akt pathway and elevation of TS expression could be blocked by LY294002, a specific inhibitor of the PI3K signaling pathway. These results implied that B7-H3 can induce colorectal cancer cell resistance to 5-FU by increasing TS expression and PI3K/Akt/TS signaling and plays an important role during these processes. This study provides more proof concerning the non-immunology effect of B7 molecules, a reminder that both co-stimulatory or inhibitory effects and non-immunology effects should be devoted equal attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.